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- Neutropenic sepsis is the occurrence of sepsis in patients who have a neutrophil count of <1.0×10 9 /L. Neutrophils are essential for a full immune response to infection, and neutropenic patients are unable to fight off infections untreated.
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Neutropenic sepsis (NS) is a common and predictable complication of bone marrow disorders and cytotoxic chemotherapy, with an estimated incidence of 70–100% during the neutropenic phase after intensive chemotherapy. 1 Patients with neutropenia are vulnerable to invasive infection, which can be rapidly overwhelming, causing septic shock and death.
- Rachel T Clarke, Tom Jenyon, Victoria van Hamel Parsons, Andrew J King
- 10.7861/clinmedicine.13-2-185
- 2013
- Clin Med (Lond). 2013 Apr; 13(2): 185-187.
Neutropenic sepsis is a life threatening complication of anticancer treatment, the term is used to describe a significant inflammatory response to a presumed bacterial infection in a person with or without fever.
- National Collaborating Centre for Cancer (UK)
- 2012/09
Mar 2, 2011 · Neutropenic sepsis is the occurrence of sepsis in patients who have a neutrophil count of <1.0×10 9 /L. Neutrophils are essential for a full immune response to infection, and neutropenic patients are unable to fight off infections untreated.
Sepsis is a leading cause of mortality in neutropenic cancer patients. Early initiation of effective causative therapy as well as intensive adjunctive therapy is mandatory to improve outcome. We give recommendations for the management of adults with neutropenia and sepsis.