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   What is scrub typhus?

   • Scrub typhus, also known as bush typhus, is a disease caused by bacteria called Orientia tsutsugamushi. Scrub typhus is spread to people through bites of infected chiggers (larval mites). The most common symptoms of scrub typhus include fever, headache, body aches, and rash.

   About Scrub Typhus | Typhus Fevers | CDC

   www.cdc.gov/typhus/about/scrub.html

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   How is scrub typhus diagnosed?

   • A reliable diagnostic laboratory test in the early phase of illness is not readily available; therefore, diagnosis is based on clinical findings and epidemiologic setting. Treatment should never be withheld pending diagnostic tests. Serologic assays are the most frequently used methods for confirming cases of scrub typhus.

   Clinical Overview of Scrub Typhus | Typhus Fevers | CDC

   www.cdc.gov/typhus/hcp/clinical-overview/clinical-overview-of-scrub-typhus.html

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   What is the treatment for severe scrub typhus?

   • Patients who were 15 years of age or older with severe scrub typhus with at least one organ involvement were enrolled. The patients were assigned to receive a 7-day course of intravenous doxycycline, azithromycin, or both (combination therapy).

   Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typh…

   www.nejm.org/doi/full/10.1056/NEJMoa2208449

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   What antimicrobials are used to treat scrub typhus?

   • Tetracycline and rifampicin are also effective antimicrobials for scrub typhus. Doxycycline It has been the mainstay of treatment for most rickettsial diseases, including scrub typhus given at a dose of 100 mg IV or orally twice daily for 7 to 14 days. However, several reports have indicated suspected doxycycline resistance.

   Scrub Typhus - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK558901/

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2. www.cdc.gov › typhus › aboutAbout Scrub Typhus | Typhus Fevers | CDC

   www.cdc.gov › typhus › about

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   May 15, 2024 · Treatment. Scrub typhus should be treated with the antibiotic doxycycline. Doxycycline can be used in persons of any age. Antibiotics are most effective if given soon after symptoms begin. People who are treated early with doxycycline usually recover quickly.

3. www.merckmanuals.com › scrub-typhusScrub Typhus - Infectious Diseases - Merck Manual ...

   www.merckmanuals.com › scrub-typhus

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   Scrub typhus is a mite-borne disease caused by Orientia tsutsugamushi and transmitted by chiggers. Antibiotics are most effective if given soon after symptoms begin, and doxycycline or chloramphenicol are the drugs of choice.

4. www.uptodate.com › contents › scrub-typhusScrub typhus - UpToDate

   www.uptodate.com › contents › scrub-typhus

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   Jan 8, 2024 · Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi. It is endemic in the rural Asian tropics and has fever, cough, rash, and eschar as symptoms. Treatment is with doxycycline or azithromycin.

5. www.ncbi.nlm.nih.gov › books › NBK558901Scrub Typhus - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK558901

   Mar 17, 2024 · Antimicrobial Treatment for Scrub Typhus Doxycycline: Doxycycline, commonly used as the primary treatment for most rickettsial diseases, is administered at 100 mg intravenously (IV) or orally twice daily for 7 to 14 days.

   • Author: O B. Singh, Prasan K. Panda

   • Published: 2022/09/26

6. www.ncbi.nlm.nih.gov › pmc › articlesAntibiotics for treating scrub typhus - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 24, 2018 · Tetracycline, doxycycline, azithromycin, and rifampicin are effective antibiotics for scrub typhus treatment that have led to few treatment failures. For specific outcomes, some low‐certainty evidence suggests there may be little or no difference between tetracycline, doxycycline, and azithromycin.

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8. www.nejm.org › doi › fullIntravenous Doxycycline, Azithromycin, or Both for Severe ...

   www.nejm.org › doi › full

   Mar 1, 2023 · Combination therapy with intravenous doxycycline and azithromycin was a better therapeutic option for the treatment of severe scrub typhus than monotherapy with either drug alone. (Funded by...