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  2. Feb 23, 2024 · Nitrosamines. This compound is at the heart of why nitrates and nitrites are considered toxic. Nitrosamines are a carcinogen, or a cancer-causing substance. They are found everywhere in our...

  3. Abstract. Sodium nitrite is a powerful oxidizing agent that causes hypotension and limits oxygen transport and delivery in the body through the formation of methemoglobin. Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death.

    • Matthew R. Neth, Jennifer S. Love, B. Zane Horowitz, Michael D. Shertz, Ritu Sahni, Mohamud R. Daya
    • 2021
  4. In aqueous environments, nitrate and nitrite salts such as sodium nitrate, potassium nitrate, sodium nitrite, and potassium nitrite rapidly ionize. Sodium nitrate is approximately 27% sodium and 73% nitrate. To determine a nitrate dose from a sodium nitrate source, the quantity of sodium nitrate is multiplied by the nitrate proportion (0.73).

    • 2017/07
  5. May 20, 2015 · According to the Centers for Disease Control and Prevention (CDC), your daily intake of sodium nitrate shouldn’t be more than 3.7 milligrams per kilo of body weight. So, for example, a person...

  6. The Bottom Line. Nitrates and nitrites are abundant in the environment and are found in medicines and products in the home. Overexposure to nitrates and nitrites can lead to a condition called methemoglobinemia in which the body is deprived of oxygen, causing a blue-gray discoloration of the skin. The Full Story.

  7. Oct 27, 2022 · Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.

  8. Introduction. General principles of supportive care, with attention to removal of the cause, will suffice for most identified cases of methemoglobinemia resulting from nitrates and nitrites. Not all patients require specific antidotal therapy.

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