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Producing enough penicillin
- The problem was in producing enough penicillin. Thousands of milk bottles produced only enough penicillin to treat four mice – though the mice recovered. In 1941, it was tested on a human and, though he died when the penicillin ran out, it was obvious that it was effective.
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Fleming found that his "mold juice" was capable of killing a wide range of harmful bacteria, such as streptococcus, meningococcus and the diphtheria bacillus. He then set his assistants, Stuart Craddock and Frederick Ridley, the difficult task of isolating pure penicillin from the mold juice.
Initially, his research was not accepted, but Fleming continued undaunted and in 1922, he discovered lysozyme, an enzyme with weak antibacterial properties. History tells us that, while infected with a cold, Fleming transferred some of his nasopharyngeal mucus onto a Petri dish.
- Siang Yong Tan, Yvonne Tatsumura
- 10.11622/smedj.2015105
- 2015
- Singapore Med J. 2015 Jul; 56(7): 366-367.
Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield and former student of Fleming, was the first to use penicillin successfully for medical treatment. [36] He cured eye infections ( conjunctivitis) of one adult and three infants ( neonatal conjunctivitis) on 25 November 1930.
Fleming’s legendary discovery of penicillin occurred in 1928, while he was investigating staphylococcus, a common type of bacteria that causes boils and can also cause disastrous infections in patients with weakened immune systems.
May 13, 2024 · In 1928 Alexander Fleming noticed that a culture plate of Staphylococcus aureus bacteria had become contaminated by a fungus. The mold, later identified as Penicillium notatum (now classified as P. chrysogenum ), had inhibited the growth of the bacteria.
Sep 27, 2013 · Actually, Fleming had neither the laboratory resources at St. Mary’s nor the chemistry background to take the next giant steps of isolating the active ingredient of the penicillium mold juice,...
May 7, 2018 · Updated on May 07, 2018. In 1928, bacteriologist Alexander Fleming made a chance discovery from an already discarded, contaminated Petri dish. The mold that had contaminated the experiment turned out to contain a powerful antibiotic, penicillin.
