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    • Image courtesy of frontiersin.org

      frontiersin.org

      • The immune suppressed state can modify the cardinal signs of inflammation, making accurate and rapid diagnosis of infection and sepsis difficult. Empiric antimicrobial agents can be lifesaving in these patients, but managing therapy in an era of progressive antibiotic resistance has become a real issue.
      pubmed.ncbi.nlm.nih.gov › 25939918

      Sepsis in the severely immunocompromised patient - PubMed

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  3. www.ncbi.nlm.nih.gov › pmc › articlesThe Clinical Challenge of Sepsis Identification and Monitoring

    May 17, 2016 · The diagnosis of sepsis in critically ill patients is challenging, because it can be complicated by the presence of inflammation as a result of other underlying disease processes and prior use of antibiotics making cultures negative.

    • Table 1

      Sepsis Marker; Increases or stays high Low or decreasing; Is...

    • Figure

      Diagnosing sepsis from infection. An infection can be...

  4. www.ncbi.nlm.nih.gov › pmc › articlesDiagnostic Challenges in Sepsis - PMC - National Center for ...

    Oct 25, 2021 · Similarly, PCT exhibits a lower diagnostic AUROC and sensitivity for predicting bacterial infection in patients with renal impairment (defined by an estimated glomerular filtration rate < 30 mL/min/1.72 m 2) , immunocompromised patients and in patients with autoimmune conditions .

    • Chris F. Duncan, Taryn Youngstein, Taryn Youngstein, Marianne D. Kirrane, Marianne D. Kirrane, Dagan...
    • 2021

  5. academic.oup.com › jid › articleSepsis in Immunocompromised Patients Without Human ...

    Jul 21, 2020 · Although immunocompromised patients are at high risk of sepsis and septic shock , it has been observed that their mortality rate due to sepsis is no greater, and is in some cases less [3, 9, 10], than the rate seen in nonimmunocompromised patients [6, 11–15].

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020

  6. pubmed.ncbi.nlm.nih.gov › 32691837Sepsis in Immunocompromised Patients Without Human ... - PubMed

    Jul 21, 2020 · A consequence of the need for this permanent immunosuppression is the high risk of opportunistic, community, and hospital-acquired infections, all of which can lead to sepsis. In addition, the detection of serious infections may be more challenging owing to patients' lower ability to mount the clinical symptoms that usually accompany sepsis.

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020

  7. www.aafp.org › pubs › afpSepsis: Diagnosis and Management - AAFP

    Although many patients with sepsis have fever, the clinical manifestation can be subtle, particularly in older patients and those who are immunocompromised. Initial evaluation of...

  8. journals.lww.com › jaapa › FulltextInfectious disease considerations in immunocompromised patients

    Overwhelming postsplenectomy infection (OPSI) refers to the development of fulminant sepsis in patients with asplenia, often due to encapsulated organisms causing meningitis or pneumonia. 6 A patient with OPSI can present with mild symptoms of infection, such as mild flu-like illness, and rapidly progress to fulminant sepsis and death. 6 ...

  9. www.cdc.gov › sepsis › hcpCaring for Patients with Sepsis | Sepsis | CDC

    Mar 8, 2024 · Start antibiotics as soon as possible in addition to other therapies appropriate for the patient. If a specific bacterial cause of sepsis is known, therapy should be targeted to optimize treatment, and broad-spectrum antibiotics might not be needed. Check patient progress frequently. Treatment requires urgent medical care, usually in an ...