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Mar 1, 2017 · Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue.
- Table - PMC - National Center for Biotechnology Information
List of Clinical Studies on Dengue Therapeutics. Compound...
- Molecular Mechanisms of Antiviral Agents against Dengue Virus
Evaluations of combinations of antiviral drugs with...
- Table - PMC - National Center for Biotechnology Information
Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.
- 10.3390/v15030705
- 2023/03
- Viruses. 2023 Mar; 15(3): 705.
Apr 18, 2023 · The DENV genome consists of a single-stranded positive-sense RNA that encodes for three structural (capsid, prM/M, and E) and seven non-structural proteins that are translated during the virus replication cycle [ 2 ]. The virus is spread by an infected mosquito bite during a blood meal and exists in both sylvatic and urban ecosystems [ 3 ].
Sep 30, 2021 · Table 1 shows a list of compounds that target the dengue virus, for which crystal structures with the target was solved, divulging a binding site, and potentially supporting a mechanism of action.
Nov 9, 2021 · The search for specific dengue inhibitors is expanding, and the mechanisms for evaluating the efficacy of novel drugs are currently established, allowing for expedited translation into human trials. Furthermore, in the aftermath of the only FDA-approved vaccine, Dengvaxia, a safer and more effective dengue vaccine candidate is making its way ...
- Harun Norshidah, Harun Norshidah, Ramachandran Vignesh, Ngit Shin Lai
- 10.3390/molecules26226768
- 2021
- Molecules. 2021 Nov; 26(22): 6768.
Oct 6, 2021 · Several challenges have precluded the development of such a therapeutic: it must be administered orally, must rapidly lower the amount of virus in the bloodstream to stem progression to severe...
There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies.
