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Regained their ability to hear
- In the recessive deafness model, gene therapy with TMC1 restored the ability of sensory hair cells to respond to sound—producing a measurable electrical current—and also restored activity in the auditory portion of the brainstem. Most importantly, the deaf mice regained their ability to hear.
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Jul 8, 2015 · Tmc gene therapy restores auditory function in deaf mice. Sci Transl Med. 2015 Jul 8;7 (295):295ra108. doi: 10.1126/scitranslmed.aab1996. Authors. Charles Askew 1 , Cylia Rochat 2 , Bifeng Pan 3 , Yukako Asai 3 , Hena Ahmed 3 , Erin Child 3 , Bernard L Schneider 2 , Patrick Aebischer 2 , Jeffrey R Holt 4. Affiliations.
Jan 22, 2019 · In the ear, we used the Anc80L065 capsid in a gene therapy study focused on Usher Syndrome, type IC, and found an unprecedented level of auditory recovery in deaf mice exposed to sAAVs...
- Carl A. Nist-Lund, Bifeng Pan, Bifeng Pan, Amy Patterson, Yukako Asai, Yukako Asai, Tianwen Chen, Wu...
- 2019
Jul 8, 2015 · In the recessive deafness model, gene therapy with TMC1 restored the ability of sensory hair cells to respond to sound—producing a measurable electrical current—and also restored activity in the auditory portion of the brainstem. Most importantly, the deaf mice regained their ability to hear.
To investigate gene therapy as a potential biologic strategy for restoration of auditory function in patients with genetic hearing loss, we tested a gene augmentation approach in mouse models of genetic deafness.
May 12, 2023 · Abstract. Progress in deciphering the genetic architecture of human sensorineural hearing impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the elucidation...
Tmc1 gene therapy restores cochlear function. To investigate the extent of recovery from sAAV-Tmc1 at the level of the whole cochlea, we measured auditory brainstem responses...
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related to: Does TMC gene therapy restore auditory function in deaf mice?Pfizer's Gene Therapy Is In Clinical Trials For DMD And Is Not FDA Approved. Learn More About Current Research And Considerations For Gene Therapy For DMD.
