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- Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases.
www.ncbi.nlm.nih.gov › pmc › articles
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Nov 3, 2021 · Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.
Nov 18, 2021 · Scientists recently gained insights into how vitamin D functions to reduce inflammation caused by immune cells that might be relevant to the responses during severe COVID-19. In a study jointly published by Purdue University and the National Institutes of Health, scientists do just that.
Nov 3, 2021 · Here, we review recent evidence associated with the relationship between vitamin D and inflammatory diseases and describe the underlying immunomodulatory effect of vitamin D. Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase.
- Tomoka Ao, Junichi Kikuta, Masaru Ishii
- 2021
Jul 15, 2020 · To sum up, vitamin D is essential for host inflammatory response to TB. Vitamin D deficiency is associated with an increased risk for developing active TB infection. However, whether supplementation of vitamin D can improve treatment outcomes for TB is still to be clarified due to differences in the results across the clinical trials.
- Nipith Charoenngam, Nipith Charoenngam, Michael F. Holick
- 10.3390/nu12072097
- 2020
- Nutrients. 2020 Jul; 12(7): 2097.
Aug 29, 2022 · Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate and adaptive immune system and endothelial membrane stability.
May 18, 2021 · Vitamin D has shown antimicrobial as well as anti-inflammatory properties. While SARS-CoV-2 promotes the release of proinflammatory cytokines, vitamin D attenuates the release of at least some of these same molecules.
