Yahoo Web Search

Search results

1. www.ncbi.nlm.nih.gov › pmc › articlesFibronectin 1 promotes melanoma proliferation and metastasis by...

   www.ncbi.nlm.nih.gov › pmc › articles

   May 1, 2019 · Fibronectin 1 (FN1) is a member of the glycoprotein family that is widely expressed by multiple cell types. 12 FN1 plays a major role in cell adhesion, growth, migration and differentiation, and it is important for processes such as wound healing and embryonic development. 13 Degradation or organization of FN1 expression has been associated ...

   • Figure 2A

     FN1 was upregulated in metastatic melanoma cells compared to...

   • Figure 7B

     (B) The correlation among FN1, ITGB1, ITGA5, TGFB1, HGF,...

   • PMC Free Article

     Results. Mean tissue specific FN1 mRNA expression was found...

   • Circulating Tumor Cells

     The presence of circulating tumor cells (CTC) accompanies...

   • An Overview

     Metastatic melanoma continues to be a challenging disease to...

2. www.nature.com › articles › s41379/021/00786-xCalcified chondroid mesenchymal neoplasms with FN1-receptor ...

   www.nature.com › articles › s41379/021/00786-x

   Jul 4, 2019 · Fusions of FN1 to FGFR1 or FGFR2 have been reported in nine soft tissue chondromas, mostly demonstrated indirectly by FISH analysis. ... of bland spindled to stellate cells with associated ...

   • Author: Yajuan J Liu, Wenjing Wang, Jeffrey Yeh, Yu Wu, Jose G Mantilla, Christopher D M Fletcher, Robert W ...

   • Publish Year: 2021

3. People also ask

   Is FN1 expressed in melanoma?

   • In consistence with those known features of FN1, the data from GEPIA confirmed that FN1 expression in tumorous tissues was higher than that in normal non-tumorous tissues ( Figure S1A) and the data from the Cancer Cell Line Encyclopedia showed that FN1 was highly expressed in melanoma compared with other cell types ( Figure S1B ).

   Fibronectin 1 promotes melanoma proliferation and metastasis by

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6503329/

   See all results for this question

   Why is FN1 expression altered in melanoma and NSCLC?

   • FN1 expression and organization is altered in cancer mainly due to the pathological activity of CAFs, and in particular of specific CAF subtypes, that are emerging as significantly correlated with an immunosuppressive environment and associated with primary resistance to immunotherapies in patients with melanoma and NSCLC [ 132 ].

   Fibronectin as a multiregulatory molecule crucial in tumor matrisome: fr…

   jeccr.biomedcentral.com/articles/10.1186/s13046-021-01908-8

   See all results for this question

   Does FN1 regulate EMT in melanoma?

   • These data suggest that EMT regulated by FN1 via interacting with integrin and downstream signaling pathways in melanoma. Extensive studies are needed for the precise mechanism. Our study found that FN1 survived from melanoma metastasis and that FN1 expression level was increased in metastatic tumor cells.

   Fibronectin 1 promotes melanoma proliferation and metastasis by

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6503329/

   See all results for this question

4. www.nature.com › articles › modpathol2013228A novel hypoxia-associated subset of FN1highMITFlow melanoma ...

   www.nature.com › articles › modpathol2013228

   Jan 3, 2014 · In conclusion, we identified a novel clinically relevant FN1highMITFlow cell type in melanoma associated with ischemic necrosis, and propose that these cells reside at the crossroad of the ...

   • Author: Jasper Wouters, Marguerite Stas, Olivier Govaere, Kathleen Barrette, Aleksandra Dudek, Hugo Vankelec...

   • Publish Year: 2014

5. jeccr.biomedcentral.com › articles › 10Fibronectin as a multiregulatory molecule crucial in tumor ...

   jeccr.biomedcentral.com › articles › 10

   • Cached

   Mar 17, 2021 · FN1 as player in metastatic process and as diagnostic and therapeutic target. At the primary tumor site, the cancer cells and cancer associated fibroblasts (CAFs) deposit FN1. FN1 activates intracellular signaling, mediated by integrins, TLRs, Wnt/β catenin, and P13K, that lead to an increase of expression and secretion of FN1, MMPs, TGFβ.

   • Author: Sheila Spada, Annalisa Tocci, Francesca Di Modugno, Paola Nisticò

   • Publish Year: 2021

6. pubmed.ncbi.nlm.nih.gov › 24390218A novel hypoxia-associated subset of FN1 high MITF low ...

   pubmed.ncbi.nlm.nih.gov › 24390218

   In conclusion, we identified a novel clinically relevant FN1(high)MITF(low) cell type in melanoma associated with ischemic necrosis, and propose that these cells reside at the crossroad of the epithelial-to-mesenchymal transition and stem-like cell induction, plausibly triggered by the hypoxic environment.

7. www.ncbi.nlm.nih.gov › pmc › articlesFN1 is a prognostic biomarker and correlated with immune ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 23, 2022 · Abstract. Fibronectin 1 (FN1) is a glycoprotein found throughout the extracellular matrix that has a role in the onset and progression of cancer. However, its immune relationship with gastric cancer is still unclear. FN1 was systematically reviewed by Gene Expression Profiling Interactive Analysis (GEPIA), Linked Omics, Tumor IMmune Estimation ...

8. www.sciencedirect.com › science › articleA novel hypoxia-associated subset of FN1highMITFlow melanoma ...

   www.sciencedirect.com › science › article

   Aug 1, 2014 · Main. Cutaneous melanoma is notorious for its heterogeneity, both at morphologic and phenotypic levels. 1, 2 In contrast to the homogeneous appearance of in vitro melanoma cell lines, the remarkable heterogeneity of in vivo cutaneous melanoma suggests an important role of the tumor microenvironment in determining the morphology and phenotype and, consequently, the function of subsets of ...