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Combination therapy is a common practice in antiviral treatment and a potential approach to search for new treatments for infectious pathogens. In this study, we performed a combination treatment in cell culture by using three distinct classes of inhibitors, including ribavirin (a guanosine analog with several antiviral mechanisms), brequinar ...
Apr 18, 2023 · There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies.
- 10.1007/s40506-023-00263-w
- 2023
Mar 21, 2018 · Nowadays, the use of adequate drug combinations allows to increase beneficial effects using lower doses of each constituent and therefore to reduce their adverse effects, as well as to...
- Amador García-Fuente, Fernando Vázquez, José M. Viéitez, Francisco J. García Alonso, Francisco J. Ga...
- 2018
Jul 9, 2020 · Combinations of three or more drugs are routinely used in various medical fields such as clinical oncology and infectious diseases to prevent resistance or to achieve synergistic therapeutic benefits.
- Melike Cokol-Cakmak, Selim Cetiner, Nurdan Erdem, Feray Bakan, Murat Cokol
- 2020
Jul 9, 2020 · These results show that testing only the top seven combinations predicted by our method would have been sufficient to identify the most synergistic three-drug combinations in the entire three-drug combination space, which corresponds to a five-fold increase in the efficiency of synergy screening.
- Melike Cokol-Cakmak, Selim Cetiner, Nurdan Erdem, Feray Bakan, Murat Cokol
- 10.1371/journal.pone.0235929
- 2020
- PLoS One. 2020; 15(7): e0235929.
Feb 7, 2019 · Synergistic drug combinations consist of two or more active pharmaceutical ingredients (APIs), which are developed to target multiple diseases or conditions, such as Exforge (amlodipine/valsartan). Accumulated studies have shown that synergistic drug combinations are widely used in the treatment of cancer, AIDs and other complex diseases [12,16].
Mar 13, 2019 · Relying on approved drug combinations for hypertension and cancer, we find that only one of the six classes correlates with therapeutic effects: if the targets of the drugs both hit disease...
