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1. ncbi.nlm.nih.gov › pmc › articlesDengue: Update on Clinically Relevant Therapeutic Strategies and...

   ncbi.nlm.nih.gov › pmc › articles

   Apr 18, 2023 · A preliminary randomized placebo-controlled clinical trial (SLCTR/2014/023) testing efficacy of rupatadine for acute dengue patients revealed improved platelet counts, reduction in liver transaminases suggesting reduced tissue inflammation, and reduction in volume of plural effusions on certain days of the study protocol in their post hoc ...

   • Figure - PMC - National Center for Biotechnology Information

     Dengue viruses (DENV) continue to circulate worldwide,...

   • Table - PMC - National Center for Biotechnology Information

     Randomized double-blind placebo-controlled trial ... and...

   • Management of Dengue: An Updated Review - PMC

     Khan Assir MZ, Kamran U, Ahmad HI, et al. Effectiveness of...

   • Current Status of Dengue Therapeutics Research and ...

     These trials have all used the conventional double-blinded,...

2. www.thelancet.com › journals › langloLong-term efficacy and safety of a tetravalent dengue vaccine ...

   www.thelancet.com › journals › langlo

   Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4·5-year results from a phase 3, randomised, double-blind, placebo-controlled trial - The Lancet Global Health. Articles | Volume 12, ISSUE 2, e257-e270, February 2024. Download Full Issue.

3. People also ask

   How effective is dengue treatment against hospitalised virologically confirmed dengue?

   • The corresponding efficacy against hospitalised virologically confirmed dengue was 96·4% (72·2–99·5) and 93·7% (72·4–98·6), respectively. The numerical differences need cautious interpretation in view of above-described fluctuations in estimates in yearly intervals.

   Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003

   www.thelancet.com/journals/langlo/article/PIIS2214-109X(23)00522-3/fulltext

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   Which drugs are used in clinical trials for dengue?

   • The most recent proof-of-concept clinical trials for dengue have been performed using repurposed or off-patent drugs, namely chloroquine, prednisolone, balapiravir, celgosivir, and lovastatin (Table 1 ). These trials have all used the conventional double-blinded, randomized, placebo-controlled design with clearly defined primary end points.

   Current Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/

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   How is severe dengue managed?

   • Judicious fluid resuscitation during the critical phase of dengue is the cornerstone of management. Crystalloids are the initial fluid of choice. Prophylactic platelet transfusion is not recommended. Organ involvement in severe dengue should be carefully looked for and managed.

   Management of Dengue: An Updated Review - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9793358/

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4. www.nejm.org › doi › fullEfficacy of a Tetravalent Dengue Vaccine in Healthy Children ...

   www.nejm.org › doi › full

   Nov 6, 2019 · Methods. We present primary efficacy data from part 1 of an ongoing phase 3 randomized trial of a tetravalent dengue vaccine candidate (TAK-003) in regions of Asia and Latin America in which...

   • Author: Shibadas Biswal, Humberto Reynales, Xavier Saez-Llorens, Pio Lopez, Charissa Borja-Tabora, Pope Kosa...

   • Publish Year: 2019

5. www.nejm.org › doi › fullEfficacy and Long-Term Safety of a Dengue Vaccine in Regions ...

   www.nejm.org › doi › full

   Sep 24, 2015 · A recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) has been assessed in two phase 3 randomized efficacy trials involving more than 31,000 children between the ages of 2 and...

   • Author: Hadinegoro, Arredondo-García Jl, Capeding Mr, Deseda C, Chotpitayasunondh T, Dietze R, Muhammad Isma...

   • Publish Year: 2015

6. www.nejm.org › doi › fullDengue | New England Journal of Medicine

   www.nejm.org › doi › full

   Apr 12, 2012 · The establishment of a therapeutic pipeline and the design of randomized, controlled trials of drugs targeting the virus or the immune response are recent developments.

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