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Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases are enzymes that cleave sialic acid (also called neuraminic acid) groups from glycoproteins.
Jan 29, 2019 · Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness.
- Julie L. McAuley, Brad P. Gilbertson, Sanja Trifkovic, Sanja Trifkovic, Lorena E. Brown, Jennifer L....
- 10.3389/fmicb.2019.00039
- 2019
- Front Microbiol. 2019; 10: 39.
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review.
- Y A Shtyrya, L V Mochalova, N V Bovin
- Acta Naturae. 2009 Jul; 1(2): 26-32.
- 2009
- 2009/07
Neuraminidase cleaves the sialic acid molecule, thereby freeing the virus to infect other cells in the host organism. Antibodies against neuraminidase that are generated by the host’s immune system following infection bind to a portion of the neuraminidase antigen known as an epitope. This binding targets the virus particles for immune destruction.
- Kara Rogers
The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. Viral neuraminidase was the first neuraminidase to be identified. It was discovered in 1957 by Alfred Gottschalk at the Walter and Eliza Hall Institute in Melbourne. [1] .
Nov 15, 2021 · Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity, immunogenicity, and immune protective potential.
Apr 28, 2004 · It is believed that the major function of viral neuraminidase (NA) is at the final stage of infection when NA cleaves sialic acid from cell surface and progeny virions facilitating virus release from infected cells ( 1, 2 ). Less is known about NA functions during virus entry into the cell.
