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The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. [1] The pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain. The ventral striatum includes the nucleus accumbens and the olfactory tubercle. [2]
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What is the mesocorticolimbic pathway?
What is the mesolimbic pathway?
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The mesolimbic pathway is a neural pathway that transports dopamine from the ventral tegmental area (VTA) to the nucleus accumbens, amygdala, and hippocampus. It is associated with reward, desire, and cognitive sensations, and has been implicated in conditions like addiction and depression.
Sep 8, 2021 · In this review, we provide an overview of preclinical findings regarding the adolescent development of mesocorticolimbic DA pathways, by both situating it within a historical context and by emphasizing novel advances in understanding its cellular and molecular underpinnings.
- Lauren M. Reynolds, Lauren M. Reynolds, Cecilia Flores
- 10.3389/fncir.2021.735625
- 2021
- Front Neural Circuits. 2021; 15: 735625.
In this review, we provide an overview of preclinical findings regarding the adolescent development of mesocorticolimbic DA pathways, by both situating it within a historical context and by emphasizing novel advances in understanding its cellular and molecular underpinnings.
The mesocorticolimbic pathway originates through the VTA and passes through the amygdala, nucleus accumbens, and hippocampus. These functions are relative to memory, emotional regulation, motivation, and reward.
The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning.
The mesocortical pathway refers to the neural connection between the ventral tegmental area (VTA) and the frontal cortex. It is closely linked to the mesolimbic pathway and is thought to function abnormally in individuals with neuropsychiatric disorders like schizophrenia.
