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Oct 14, 2021 · 1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Planning a Synthesis using a Reductive Amination. If you are trying to develop a synthesis of an amine molecule, the key bond break is a C-N bond in the target molecule. There may be multiple C-N bonds present, so each should be broken separately to produce a possible set of starting materials.
Jan 1, 2016 · Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1 ).
- Identification
- Pharmacology
- Interactions
- Chemical Identifiers
- Clinical Trials
- Pharmacoeconomics
- Properties
Generic Name
1. 1-Phenylcyclohexylamine
DrugBank Accession Number
1. DB01506
Background
1. Not Available
Indication
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Contraindications & Blackbox Warnings
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Pharmacodynamics
1. Not Available
Drug Interactions information
1. This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist. Not Available
Food Interactions
1. Not Available
UNII
1. HBO2D49I2S
CAS number
1. 2201-24-3
InChI Key
1. RGZGRPPQZUQUCR-UHFFFAOYSA-N
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Manufacturers
1. Not Available
Packagers
1. Not Available
Dosage Forms
1. Not Available
A series of phencyclidine homologs was synthesized by reductive cyclization of substituted ω-chlorine-substituted l-N- [l- (p-hydroxybenzyl)cyclohexyl]amides with LiAlH4 by characterized and tested for neurotropic activity. Expand. 1. Synthesis and biological activity of cyclohexylamine derivatives. V. A. Glushkov O. S. P’yankova. +4 authors.
Jul 21, 2023 · Part A. Concepts -- 1. The drug discovery process -- 2. Drug synthesis -- 3. Retrosynthesis -- 4. Cyclic systems in drug synthesis -- 5. The synthesis of chiral drugs -- 6. Combinatorial and parallel synthesis -- Part B. Applications of drug synthesis in the drug development process -- 7. Synthesis of lead compounds -- 8.
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Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
