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Jan 28, 2021 · demonstrated multiple NLS in Dengue virus, particularly in protein N5, while Wagstaff et al. showed that ivermectin could clearly block Dengue virus replication. Our analysis of the proteins of Dengue virus 2 found four of the ten major proteins had possible NLS that would allow transit into the nucleus (Table (Table4). 4). This might explain ...
Jun 10, 2021 · Recent field trials have demonstrated that dengue incidence can be substantially reduced by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquito populations. This strategy relies on Wolbachia reducing the susceptibility of Ae. aegypti to disseminated infection by positive-sense RNA viruses like dengue.
Nov 21, 2022 · Dengue virus (DENV) infection is one of the major public health concerns around the globe, especially in the tropical regions of the world that contribute to 75% percent of dengue cases. While the majority of DENV infections are mild or asymptomatic, approximately 5% of the cases develop a severe form of the disease that is mainly attributed to ...
Dec 8, 2010 · Abstract. Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [ 1 ], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon.
Oct 10, 2018 · Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There are four serotypes of the virus. Each serotype is antigenically different, meaning they elicit heterologous antibodies. Infection with one serotype will create ...
Mar 6, 2024 · Dengue is a mosquito-transmitted virus and is the leading cause of arthropod-borne viral disease worldwide, posing a significant global health concern. This disease is also known by various monikers, such as breakbone or 7-day fever, and is characterized by intense muscle spasms, joint pain, and high fever, reflecting both the severity and the duration of symptoms. Although most dengue fever ...
Aug 18, 2016 · This Primer provides a general overview on dengue, covering epidemiology, control, disease mechanisms, diagnosis, treatment and research priorities. Infection with any one of the four dengue virus ...
