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About. I am a third-year Ph.D. student in Operations Research at the University of Washington, with a concurrent master in Statistics. I received my B.S. in Physics and Mechanics from Fudan ...
- University of Washington
Yinsheng Wang's 447 research works with 16,536 citations and 11,552 reads, including: Publisher Correction: mA in CAG repeat RNA binds to TDP-43 and induces neurodegeneration
Oct 10, 2021 · INTRODUCTION. The genomic integrity of human cells is constantly challenged by exposure to a variety of endogenous and exogenous DNA-damaging agents. 1 Byproducts of endogenous metabolism, metabolic activation of some environmental chemicals, and cancer chemotherapeutic agents can lead to DNA alkylation, which represents one of the most common types of DNA damage. 2–4
Jun 12, 2020 · Abstract. Alkylating agents are ubiquitously present in the environment, and they can alkylate DNA and RNA directly or after metabolic activation. The focus of the present R35 application is placed on the chemistry and biology of DNA and RNA alkylation, with the overarching goal of understanding the molecular mechanisms through which alkylating ...
Jun 6, 2023 · Hence, we conclude that phase separation contributes to the stabilization of G4 structures in cells. Figure 4. 1,6-HD treatment led to diminished G4 structures in cells. (A) ChIP-seq tracks showing the transcription start site (TSS) of the CCDC88A gene in control and 1,6-HD-treated U2OS cells.
Jun 5, 2018 · RNA is known to contain more than 100 distinct types of post-transcriptional modifications, which can modulate its splicing, localization, stability, and translation. 1 It was found that methylation at the N 6 position of adenosine (m 6 A) is involved in the epigenetic control of gene regulation. 2−6 Recent transcriptome-wide mapping also revealed the presence of m 1 A in human mRNA, 7−9 ...
Nov 11, 2021 · INTRODUCTION. Melanoma is a principal cause of skin cancer mortality in the United States, accounting for an estimated 106,110 new cases and 7180 deaths in 2021. 1 Early-stage melanoma is typically curable, where a five-year survival rate of 99% was reported with localized melanoma; the prognosis, however, worsens considerably to approximately 27% for cases of distant metastasis. 2 Fortunately ...
