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Sep 20, 2019 · DENV vaccine is based on dengue–YF vaccine virus chimeras Chimeric yellow fever virus attenuated 17D (CYD). The operative hypothesis was that the attenuation characteristics of 17D YF vaccine virus will impart similar attenuation attributes to the chimera (Guirakhoo et al., 2002). Chimeric viruses are replicated by the YF RNA polymerase.
May 17, 2021 · Unlike the clinical trials mentioned thus far, Tricou et al. studied the tetravalent dengue vaccine, Takeda (TAK-003), which is scientifically designed with a DENV-2 backbone rather than the yellow fever virus, in 1794 patients living in dengue-endemic areas. 11 Healthy children aged 2–17 years were subject to a 1:2:5:1 randomization to ...
Aug 22, 2022 · About QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) QDENGA® (TAK-003) is a dengue vaccine that is based on a live-attenuated dengue serotype 2 virus, which provides the genetic “backbone” for all four dengue virus serotypes and is designed to protect against any of these serotypes. 7
Mar 13, 2023 · The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while ...
In 2016, WHO1 recommended that the dengue vaccine CYD-TDV (Dengvaxia; Pasteur, Lyon, France), the first dengue vaccine, licensed for use in adults and children aged 9 years or older, be considered for use in highly endemic regions where at least 70% of 9-year-old children had previously been infected with dengue. The Philippines was the first country to introduce Dengvaxia on a large scale in ...
Nov 7, 2023 · A key challenge for vaccine development is that dengue is caused by four distinct viral subtypes, or serotypes: DENV-1, DENV-2, DENV-3 and DENV-4. “The perfect dengue vaccine would have 90% ...
Jan 1, 2023 · Abstract. The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human, causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar conserved structure and sequence among distinct DENV serotypes or different flaviviruses has resulted in the occurrence of cross reaction followed by antibody ...
