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  1. Distance from San Diego, CA to Santa Maria, CA. There are 243.33 miles from San Diego to Santa Maria in northwest direction and 292 miles (469.93 kilometers) by car, following the US-101 N route. San Diego and Santa Maria are 4 hours 36 mins far apart, if you drive non-stop .

  2. The distance between San Diego and Santa Maria is 296 miles. The road distance is 294.4 miles. Get driving directions

  3. Driving distance from San Diego, CA to Santa Maria, CA. The total driving distance from San Diego, CA to Santa Maria, CA is 282 miles or 454 kilometers. Your trip begins in San Diego, California. It ends in Santa Maria, California.

  4. Get a quick answer: It's 282 miles or 454 km from San Diego to Santa Maria (California), which takes about 4 hours, 32 minutes to drive.

  5. driving distance = 282 miles. Driving directions from Santa Maria, CA to San Diego. From: To: What's the distance? Travel time from Santa Maria, CA to San Diego, CA. How long does it take to drive? 4 hours, 32 minutes. Find out how many hours from Santa Maria, CA to San Diego by car if you're planning a road trip.

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