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  2. Isabella of Portugal (Isabel in Portuguese and Spanish) (1428 – 15 August 1496) was Queen of Castile and León as the second wife of King John II. She was the mother of Queen Isabella I of Castile.

  3. Feb 1, 2019 · Isabella of Portugal Facts. Known for: regent of Spain during long absences of her husband, Charles V, Holy Roman Emperor. Titles: Empress, Holy Roman Empire; Queen of Germany, Spain, Naples, and Sicily; Duchess of Burgundy; princess (Infanta) of Portugal. Dates: October 24, 1503 - May 1, 1539.

  4. Contents. Isabella of Portugal. queen of Castile. Learn about this topic in these articles: execution of Luna. In Álvaro de Luna. …in 1447 John II married Isabella of Portugal, who determined to destroy Luna’s power over her husband.

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