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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
Feb 11, 2018 · Median Lethal Dose Definition. The median lethal dose, or LD50, is a term used in toxicology as a measurement of a lethal dose of a substance (e.g., pathogen, medication, toxic substance, etc.). Specifically, the LD50 represents the dose at which a substance is lethal for 50% of tested subjects.
Aug 6, 2018 · The LD 50 (median lethal dose) test was introduced in 1927 by J. W. Trevan to estimate the dose of a test substance that produces 50% death in a given species of animals. It is usually the first test conducted for every chemical before further toxicity tests are carried out.
- Earnest Oghenesuvwe Erhirhie, Chibueze Peter Ihekwereme, Emmanuel Emeka Ilodigwe
- 2018
median lethal dose. J. Shetty Akhila*, Shyamjith, Deepa and M. C. Alwar. Whenever an investigator administers a chemical substance to a biological system, different of interactions can occur and a series of dose-related responses result.
Aug 11, 2022 · The LD 50 is the dose that kills half (50%) of the animals tested (LD = "lethal dose"). It is a standardized measure for expressing and comparing the toxicity of chemicals.
One such population-level measure is the median lethal dose, LD50 (lethal dose, 50%). This is defined as the dose required to kill half the members of a specific animal population when entering the animal’s body by a particular route. LD 50 is a general indicator of a substance’s toxicity within a short space of time.
