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Definition
Immunoglobulin A (IgA) is a type of antibody. Antibodies are proteins of the immune system that bind to and neutralize pathogens such as bacteria and viruses . IgA is one of the five immunoglobulin classes (in addition to IgG, IgM, IgD, and IgE) . In the human body, more IgA is produced per day than all other antibodies combined [2, 3, 1]. IgA is produced by white blood cells (B cells) and is then transported into fluids secreted by mucosal cells. This IgA is called the secretory IgA. S...
Function
Mucosal barriers (where IgA is present) separate the interior of the body from the outside world. At these sites,IgA maintains a balanced immune response. It defends against harmful microbes but also prevents reactions against good bacteria and environmental proteins (such as food antigens) . IgA has many important functions: 1. It is the first line of defense against harmful microbes [1, 3]. 2. It removes microbes that have breached the epithelial barrier (such as the intestinal barrier)...
Normal IgA levels vary slightly depending on the laboratory used to test them. They gradually increase with age and weight in children until they reach stable levels in adults. Blood IgA levels are higher in males than in females . These are the approximate values for IgA depending on age: 1. 0-1 years: 1-83 mg/dL 2. 1-5 years: 20-152 mg/dL 3. 5-10...
Associations with Mortality
Both low and high IgA levels are associated with higher mortality. In 4,255 Vietnam-era war veterans, higher IgA levels were associated with a 2-fold increased risk of dying from both all-causes and infectious diseases . In people aged 90 – 99 years, higher IgA levels were associated with higher mortality . Similarly, in 8-year-olds, high IgA levels (>400 mg/dl) were associated with higher mortality. IgA levels were related to cancer mortality in males . On the other hand, higher...
If you’re not a big fan of genetics, skip straight to our other posts about IgA in the next section. The following genes have been associated with IgA levels and IgA deficiency:
IgA is a type of antibody that protects the body from infection and maintains immune tolerance. Learn about IgA levels, genetics, deficiency, and how to improve them.
Sep 19, 2023 · An immunoglobulin test measures the levels of different types of antibodies in your blood or cerebrospinal fluid. Antibodies are proteins that help your body fight infections and allergies. Learn why you might need this test and what the results mean.
Learn about IgA deficiency, a genetic condition that affects your immune system and can cause infections, allergies, and autoimmune diseases. Find out the causes, symptoms, diagnosis, treatment, and prevention of this health problem.
May 24, 2024 · Selective IgA deficiency is the lack of a disease-fighting antibody in the immune system called immunoglobulin A (IgA). People with this condition usually have typical levels of other immunoglobulins (im-u-no-GLOB-u-lins).
Immunoglobulin A (IgA) is an antibody that plays a role in the immune function of mucous membranes. Learn about its forms, subclasses, physiology, and functions in this comprehensive article.
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