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Gutsy Loretta Clairborne (Kimberly Elise), born with mental and physical disabilities, realizes at an early age that she's a talented athlete. Always able to stick up for herself, Loretta is thrown out of school after a fight, but, urged on by her mother (Tina Lifford) and a devoted social worker (Camryn Manheim), she runs in Special Olympics meets and the Boston Marathon. Loretta's resolve is tested again when her mother becomes seriously ill and her own health requires attention.