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While EMTs are all business when they are in their professional posts, their personal lives can be unruly and full of ridiculous antics. Good-looking Johnny leads a crew of Chicago EMTs that includes his outspoken best friend, Hank, and an eager new recruit, Brian. They can handle any life-threatening situation that ends up in their ambulance. Chicago PD officer Theresa, who is in love purgatory with her ex, Johnny, lends a much-needed female perspective to the male-dominated group. The comedy series comes from the comedic mind of executive producer Denis Leary ("Rescue Me").