The rendering of the Central Dogma found in most standard texts, thus promulgated by many supposedly well-educated molecular biologists, and reproduced in Wikipedia, is a bowdlerization of what Crick actually had to say on the topic.https://en.wikipedia.org/wiki/Talk:Central_dogma_of_molecular_biology/Comments
The central dogma of molecular biology is an explanation of the flow of genetic information within a biological system. It is often stated as "DNA makes RNA, and RNA makes protein", although this is not its original meaning. It was first stated by Francis Crick in 1957, then published in 1958: The Central Dogma.
From Simple English Wikipedia, the free encyclopedia Information flow in biological systems The central dogma of molecular biology is a phrase by Francis Crick, who proposed the double helix structure of DNA. It means that information passes from DNA to proteins via RNA, but proteins cannot pass the information back to DNA.
The rendering of the Central Dogma found in most standard texts, thus promulgated by many supposedly well-educated molecular biologists, and reproduced in Wikipedia, is a bowdlerization of what Crick actually had to say on the topic.
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From Wikipedia, the free encyclopedia The central dogma of molecular biology is an explanation of the flow of genetic information within a biological system. It is often stated as "DNA makes RNA and RNA makes protein," although this is not its original meaning. It was first stated by Francis Crick in 1957, then published in 1958:
Transcription is the process by which the information contained in a section of DNA is transferred to a newly assembled piece of messenger RNA (mRNA). It is facilitated by RNA polymerase and transcription factors.
In eukaryote cells the primary transcript (pre-mRNA) is processed. One or more sequences (introns) are cut out. The mechanism of alternative splicing makes it possible to produce different mature mRNA molecules, depending on what sequences are treated as introns and what remain as exons. However, not all living cells have mRNA that undergoes splicing; splicing is absent in prokaryotes.
Eventually, this mature mRNA finds its way to a ribosome, where it is translated. In prokaryotic cells, which have no nuclear compartment, the process of transcription and translation may be linked together. In eukaryotic cells, the site of transcription (the cell nucleus) is usually separated from the site of translation (the cytoplasm), so the mRNA must be transported out of the nucleus into the cytoplasm, where it can be bound by ribosomes. The mRNA is read by the ribosome as triplet codons, usually beginning with an AUG, or initiator methonine codon downstream of the ribosome binding site. Complexes of initiation factors and elongation factors bring aminoacylated transfer RNAs (tRNAs) into the ribosome-mRNA complex, matching the codon in the mRNA to the anti-codon in the tRNA, thereby adding the correct amino acidin the sequence encoding the gene. As the amino acids are linked into the growing peptide chain, they begin folding into the correct conformation. This folding continue...
Molecular biology / məˈlɛkjʊlər / is the branch of biology that concerns the molecular basis of biological activity in and between cells, including molecular synthesis, modification, mechanisms and interactions. The central dogma of molecular biology describes the process in which DNA is transcribed into RNA, then translated into protein.
↑ The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that information cannot be transferred back from protein to either protein or nucleic acid. ↑ Li J, Browning S, Mahal SP, Oelschlegel AM, Weissmann C (2009). "Darwinian Evolution of Prions in Cell Culture".
From Wikipedia, the free encyclopedia The history of molecular biology begins in the 1930s with the convergence of various, previously distinct biological and physical disciplines: biochemistry, genetics, microbiology, virology and physics.
May 03, 2018 · The central dogma of molecular biology describes the process by which the information in genes flows into proteins: DNA → RNA → protein. DNA contains genes that code for proteins. RNA is the intermediate between DNA and proteins. It carries information in genes from the nucleus to the cytoplasm in eukaryotes.