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    • Selective loss of dopaminergic neurons

      • The main hallmark of Parkinson’s disease (PD), the most common progressive neurodegenerative movement disorder, is the selective loss of dopaminergic neurons (DaNs) in the substantia nigra (SN).
      www.nature.com › articles › s41467/020/17876-0

      A single-cell atlas of the human substantia nigra reveals ...

  2. www.ncbi.nlm.nih.gov › pmc › articlesParkinson’s disease progression in the substantia nigra:...

    Sep 18, 2020 · Most neuroscientists and neurologists will attest to the fact that the motor symptoms of Parkinson’s disease begin once a patient has lost a moderate number of dopaminergic neurons from the substantia nigra. Estimates place this figure at ∼30–50%.

    • David E Vaillancourt, Trina Mitchell
    • 10.1093/brain/awaa252
    • 2020
    • Brain. 2020 Sep; 143(9): 2628-2630.

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  4. www.ncbi.nlm.nih.gov › books › NBK536995Neuroanatomy, Substantia Nigra - StatPearls - NCBI Bookshelf

    Oct 24, 2022 · The substantia nigra (SN) is a midbrain dopaminergic nucleus, which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry (see Image. Substantia Nigra).

    • James Sonne, Vamsi Reddy, Morris R. Beato
    • 2022/10/24
    • 2020

  5. www.ncbi.nlm.nih.gov › books › NBK536722Parkinson’s Disease: Etiology, Neuropathology, and ...

    Dec 21, 2018 · The movement disorder arises due to the loss of dopaminergic neurons of the substantia nigra pars compacta, with the pathological hallmark being intracellular aggregates of α-synuclein, in the form of Lewy bodies and Lewy neurites.

    • Antonina Kouli, Kelli M. Torsney, Wei-Li Kuan
    • 2018/12/21
    • 2018

  6. pubs.rsna.org › doi › 10Imaging the Substantia Nigra in Parkinson Disease and Other ...

    Jun 8, 2021 · Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. There are various imaging markers for Parkinson disease. Recent advances in MRI have enabled elucidation of the underlying pathophysiologic changes in the nigral structure.

    • Yun Jung Bae, Jong Min Kim, Chul Ho Sohn, Ji Hyun Choi, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se...
    • 2021

  7. www.cambridge.org › core › journalsSubstantia Nigra and Parkinson's Disease: A Brief History of ...

    These findings have strengthened the link between the substantia nigra and Parkinson's disease, but modern research has uncovered the multifaceted nature of this neurodegenerative disorder by identifying other brain structures and chemospecifc systems involved in its pathogenesis.

    • Martin Parent, André Parent
    • 2010

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  9. www.nature.com › articles › s41467/020/17876-0A single-cell atlas of the human substantia nigra reveals ...

    Aug 21, 2020 · The main hallmark of Parkinson’s disease (PD), the most common progressive neurodegenerative movement disorder, is the selective loss of dopaminergic neurons (DaNs) in the substantia nigra (SN).

  10. www.msdmanuals.com › parkinson-diseaseParkinson Disease - Parkinson Disease - MSD Manual ...

    Atypical parkinsonism refers to a group of neurodegenerative disorders that have some features similar to those of Parkinson disease but have some different clinical features, a worse prognosis, a modest or no response to levodopa, and a different pathology (eg, neurodegenerative disorders such as multiple system atrophy, progressive supranuclea...

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