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  1. Mar 26, 2021 · The standard serologic test for diagnosis of RMSF is the indirect immunofluorescence antibody (IFA) assay for immunoglobulin G (IgG) using R. rickettsii antigen. IgG IFA assays should be performed on paired acute and convalescent serum samples collected 2–4 weeks apart to demonstrate evidence of a fourfold seroconversion.

  2. Aug 25, 2022 · Rocky Mountain spotted fever (RMSF) is a serious illness you get from a tick bite. It’s caused by the bacterium Rickettsia rickettsii. Symptoms include a high fever and headache. Rash may start three or more days after other symptoms. RMSF can be life-threatening if not treated quickly with antibiotics. RMSF is found in most states in the U.S.

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  4. Interpretation. This test detects reactivity to the group-specific rickettsia. For example, antibody reactivity to the Rickettsia rickettsii will also react with other organisms within the spotted fever group. IgG. Titer results of 1:256 and above:

  5. IgG serum endpoint titer of ≥1:64 is suggestive of infection at an unknown time and may be a sign of either past infection or early response to a recent infection. IgM titer of ≥1:64 is regarded as probable evidence of recent or ongoing infection.

  6. Jul 17, 2023 · Rocky Mountain spotted fever (RMSF) is an acute febrile tick-borne illness caused by Rickettsia rickettsii. In North America, it is both the most severe and the most common rickettsial infection. Without prompt antibiotic treatment, mortality rates are as high as 20 to 30 percent.

    • Jessica Snowden, Kari A. Simonsen
    • 2023/07/17
  7. Jul 4, 2014 · Rocky Mountain spotted fever (RMSF) is a tickborne disease caused by the bacterium Rickettsia rickettsii. This organism is a cause of potentially fatal human illness in North and South America, and is transmitted to humans by the bite of infected tick species.

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