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What are cytochrome P450 enzymes?
Are cytochrome P450 enzymes a membrane-bound hemoprotein?
What is the role of cytochrome P450 in drug therapy?
What is a cytochrome P450 test?
Function. CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic ...
- CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
Cytochrome P-450 CYP1A2. Human cytochrome P450 enzyme 1A2 (CYP1A2) is one of the most important cytochrome P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes. CYP1A2 metabolises many clinical drugs, such as phenacetin, caffeine, clozapine, tacrine, propranolol, and mexiletine. CYP1A2 also meta ….
- Jingchao Guo, Xiaohui Zhu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang
- 2021
Located on chromosome 15, CYP1A2 consists of 7,758 nucleotides and encodes the enzyme CYP1A2 that contains 516 amino acids. Polymorphisms of the CYP1 family of genes have been studied for association with cancer susceptibility.
Apr 24, 2023 · Common cytochrome p450 inducers, inhibitors, and substrates of the primary isozymes mentioned in this article are listed below. CYP1A2: Inhibitors: amiodarone, cimetidine, ciprofloxacin, fluvoxamine
- Brian Gilani, Manouchkathe Cassagnol
- 2020
Jul 24, 2018 · The cytochrome P450 enzyme includes the CYP2D6 enzyme, which processes many antidepressants and antipsychotic medications. By checking your DNA for certain gene variations, CYP450 tests can offer clues about how your body may respond to a particular antidepressant.
A classical example includes anti-epileptic drugs, such as phenytoin, which induces CYP1A2, CYP2C9, CYP2C19, and CYP3A4 . Effects on P450 isozyme activity are a major source of adverse drug interactions, since changes in P450 enzyme activity may affect the metabolism and clearance of various drugs.
Nov 26, 2021 · Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis.
