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  1. The most common causes of pre-ICU immunosuppression are solid organ transplantation, hematopoietic stem cell transplantation, and infection due to human immunodeficiency virus. In thi … Sepsis and Challenging Infections in the Immunosuppressed Patient in the Intensive Care Unit

    • Diana F. Florescu, Uriel Sandkovsky, Andre C. Kalil
    • 7
    • 2017
  2. The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and is susceptible to conventional and opportunistic pathogens. The solid organ transplant patient has a primary defect in adaptive immunity and is susceptible to a myriad of pathogens that require an effective cellular immune response.

    • Andre C. Kalil, Steven M. Opal
    • 21
    • 2015
  3. The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and is susceptible to conventional and opportunistic pathogens.

    • Andre C. Kalil, Steven M. Opal
    • Current Infectious Disease Reports
    • 2015
    • 17
  4. A consequence of the need for this permanent immunosuppression is the high risk of opportunistic, community, and hospital-acquired infections, all of which can lead to sepsis. In addition, the detection of serious infections may be more challenging owing to patients' lower ability to mount the clinical symptoms that usually accompany sepsis.

    • Randy J McCreery, Diana F Florescu, Andre C Kalil
    • 2020
  5. Sep 28, 2018 · The SIRS criteria have, since 1992, been used to screen and identify sepsis patients20. To diagnose sepsis, at least two of the four SIRS criteria must be met. However, because SIRS can be triggered by a variety of infectious and noninfectious causes, it is insufficiently sensitive, and certainly not specific for sepsis.

    • Hwan Il Kim, Sunghoon Park
    • 30
    • 2019
  6. Severe cases of sepsis often result from a body-wide infection that spreads through the bloodstream. In some cases, bloodstream infection cannot be detected, and doctors use other information such as body temperature and mental status to diagnose sepsis. Sepsis often results from infections to the lungs, stomach, kidneys, or bladder. It’s

  7. Rationale: Immunocompromised patients are at high risk for developing severe sepsis. Currently, there are no validated strategies for identifying this group of patients in large administrative databases.

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