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Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
- Cytochrome P450
structure summary. Cytochromes P450 ( P450s or CYPs) are a...
- CYP3A
The CYP3A locus includes all the known members of the 3A...
- Cytochrome P450
Apr 24, 2023 · Fundamentals. Cytochrome p450 is a superfamily of membrane-bound hemoprotein isozymes with distinct classifications. While present in most body tissues, CYP enzymes predominantly occupy the liver, intestines, and kidneys, with their highest concentration in the liver.
- Brian Gilani, Manouchkathe Cassagnol
- 2020
Mar 3, 2013 · CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 isoform (CYP3A4) is the most abundant and the most important because it metabolizes the majority of the administered drugs.
- Irina F. Sevrioukova, Thomas L. Poulos
- 10.1039/c2dt31833d
- 2013
- 2013/03/03
Mar 7, 2013 · Abstract. Cytochromes P450 (CYPs) represent a diverse group of heme-thiolate proteins found in almost all organisms. CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen.
CYP3A4 is often considered the most important drug-metabolizing enzyme, given its relatively high expression in liver and intestine.
