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Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907.
Dec 8, 2022 · Ketamine was synthesized from PCP in 1962 by the pharmaceutical company Parke-Davis (Detroit, MI, USA), which was seeking to develop new ACH anesthetics with analgesic properties . The first-in-man trial took place in 1964 at Michigan State Prison (Jackson, MI, USA).
- 10.3390/ijms232415574
- 2022/12
- Int J Mol Sci. 2022 Dec; 23(24): 15574.
Dec 17, 2020 · The two main classes of dissociatives are arylcyclohexylamine [to which ketamine, phencyclidine (PCP) and methoxetamine (MXE) belong] and diarylethylamine. PCP was first synthesised in 1956 as an anaesthetic but largely withdrawn from frontline use because of its unfavourable side effects and abuse potential.
- Abu Shafi, Alex J. Berry, Harry Sumnall, David M. Wood, Derek K. Tracy
- 2020
The vast majority of the conjectured compounds haven’t even been synthesized before. This was written before I actually started doing work with synthesizing new compounds, analyzing their binding affinity for NMDAr, and developing further compounds based on observed SAR, though almost all of my work is not with arylcyclohexylamines.
Jan 1, 2016 · Phencyclidine , the first well-known arylcyclohexamine, was first synthesized by the Parke-Davis chemist Victor Maddox in 1956. While these experiments were not reported in the literature until nearly 10 years later , the pharmacology of phencyclidine had by then already been described [6, 7].
Dec 8, 2022 · Ketamine was synthesized from PCP in 1962 by the pharmaceutical company Parke-Davis (Detroit, MI, USA), which was seeking to develop new ACH anesthetics with analgesic properties . The first-in-man trial took place in 1964 at Michigan State Prison (Jackson, MI, USA).
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Phencyclidine (PCP, “angel dust”, an arylcyclohexylamine) was the first non-natural, man-made illicit drug of abuse, and was coined ‘the most dangerous drug in America” in the late 1970s (amidst sensational horror stories of the drug’s effects); however, few other illicit drugs have had such a significant and broad impact on society ...
