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CYP2D6. Cytochrome P450 2D6 ( CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra . CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important ...
- CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6
Oct 15, 2021 · The CYP2D6*1 allele is considered the reference allele and is often inferred when no variants interrogated by a genotyping test are detected. The CYP2D6*1 allele confers normal enzyme activity and can be found in many individuals with a NM phenotype. Some groups refer to this phenotype as an “extensive” metabolizer.
- Megan Kane
- 2021/10/15
- NCBI, Email: vog.hin.mln.ibcn@sgm
Oct 30, 2020 · Copy number variation (CNV) is a type of larger structural variation and, in a diploid genome, generally refers to the presence of more or less than two copies of a gene. CNV is common in CYP2D6 and individuals, with one or three CYP2D6 copies occurs at a frequency of 12–23% depending on population ethnicity [ 40 ].
- Christopher Taylor, Ian Crosby, Vincent Yip, Peter Maguire, Munir Pirmohamed, Richard M. Turner
- 2020
Abstract. The FDA lists 22 medications as clinical inhibitors of CYP2D6, with classifications of strong, moderate, and weak. It is accepted that strong inhibitors result in nearly null enzymatic activity, but reduction caused by moderate and weak inhibitors is less well characterized. The objective was to identify if the classification of ...
- Emily J. Cicali, D. Max Smith, Benjamin Q. Duong, Lukas G. Kovar, Larisa H. Cavallari, Julie A. John...
- 10.1002/cpt.1768
- 2020
- 2020/07
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Aug 14, 2017 · The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug ...
- Johannes Hochleitner, Muhammad Akram, Martina Ueberall, Rohan A. Davis, Birgit Waltenberger, Hermann...
- 2017
May 25, 2021 · Individuals with no functional CYP2D6 (i.e., poor metabolizers) had longer LSD half-lives and approximately 75% higher parent drug and main metabolite 2-oxo-3-hydroxy LSD area-under-the-curve ...
Feb 18, 2021 · Cytochrome P450 (P450) 2D6 is a major drug-metabolizing enzyme expressed in the liver 1.CYP2D6 catalyzes the hepatic metabolism of a large number of clinically important medications, including ...
