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  1. From Wikipedia, the free encyclopedia Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ceftazidime.

    Talk:Ceftazidime - Wikipedia
  2. Ceftazidime - Wikipedia › wiki › Ceftazidime

    From Wikipedia, the free encyclopedia Ceftazidime, sold under the brand names Fortaz among others, is an antibiotic useful for the treatment of a number of bacterial infections.

    • Ceftazidime/Avibactam

      From Wikipedia, the free encyclopedia Ceftazidime/avibactam,...

    • Medical uses

      Ceftazidime is used to treat lower respiratory tract, skin,...

    • Side effects

      Ceftazidime is generally well tolerated. When side effects...

    • Mechanism of action

      Third-generation cephalosporins differ from earlier...

    • Chemistry

      In addition to the syn-configuration of the imino side...

  3. Ceftazidime — Wikipedia Republished // WIKI 2 › en › Ceftazidime
    • Medical Uses
    • Side Effects
    • Mechanism of Action
    • Chemistry

    Cef­tazidime is used to treat lower res­pi­ra­tory tract, skin, uri­nary tract, blood-stream, joint, and ab­dom­i­nal in­fec­tions, and meningitis. The drug is given in­tra­venously (IV) or in­tra­mus­cu­larly (IM) every 8–12 hours (two or three times a day), with dose and fre­quency vary­ing by the type of in­fec­tion, sever­ity, and/or renal func­tion of the per­son. Cef­tazidime is also com­monly pre­scribed off-la­bel for neb­u­liza­tion in peo­ple with cys­tic fi­bro­sis for the sup­pres­sion of Pseudomonas aeruginosain the lungs as well as the treat­ment of pul­monary ex­ac­er­ba­tions. Those with kid­ney dis­ease are dosed less frequently. Cef­tazidime is the first-line treat­ment for the trop­i­cal in­fec­tion, me­lioi­do­sis, an im­por­tant cause of sep­sis in Asia and Australia. La­beled in­di­ca­tions in­clude the treat­ment of pa­tients with: 1. Pseudomonas aeruginosainfections 2. other Gram-negative, aerobic infections 3. neutropenic fever As a class, cephalosporins hav...

    Cef­tazidime is gen­er­ally well tol­er­ated. When side ef­fects occur, they are most com­monly local ef­fects from the in­tra­venous line site, al­ler­gic re­ac­tions, and gas­troin­testi­nal symp­toms. Ac­cord­ing to one man­u­fac­turer, in clin­i­cal tri­als, al­ler­gic re­ac­tions in­clud­ing itch­ing, rash, and fever, hap­pened in fewer than 2% of pa­tients. Rare but more se­ri­ous al­ler­gic re­ac­tions, such as toxic epi­der­mal necrol­y­sis, Stevens–John­son syn­drome, and ery­thema mul­ti­forme, have been re­ported with this class of an­tibi­otics, in­clud­ing cef­tazidime. Gas­troin­testi­nal symp­toms, in­clud­ing di­ar­rhea, nau­sea, vom­it­ing, and ab­dom­i­nal pain, were re­ported in fewer than 2% of patients. An­other source re­ported, in ad­di­tion, blood tests of pa­tients may show in­creased eosinophils (8%), in­creased lac­tate de­hy­dro­ge­nase (6%), in­creased gamma-glu­tamyl trans­ferase (5%), pos­i­tive di­rect Coombs test (4%), in­creased platelets (throm­bo­...

    Third-gen­er­a­tion cephalosporins dif­fer from ear­lier gen­er­a­tions in the pres­ence of a C=N-OCH3 group in their chem­i­cal struc­ture (ce­furox­ime & ce­fu­zonam also bear this func­tional group but are only listed as class II). This group pro­vides im­proved sta­bil­ity against cer­tain beta-lac­ta­maseen­zymes pro­duced by Gram-neg­a­tive bac­te­ria. These bac­te­r­ial en­zymes rapidly de­stroy ear­lier-gen­er­a­tion cephalosporins by break­ing open the drug's beta-lac­tam chem­i­cal ring, lead­ing to an­tibi­otic re­sis­tance. Though ini­tially ac­tive against these bac­te­ria, with wide­spread use of third-gen­er­a­tion cephalosporins, some Gram-neg­a­tive bac­te­ria that pro­duce ex­tended-spec­trum beta-lac­ta­mases (ESBLs) are even able to in­ac­ti­vate the third-gen­er­a­tion cephalosporins. In­fec­tions caused by ESBL-pro­duc­ing Gram-neg­a­tive bac­te­ria are of par­tic­u­lar con­cern in hos­pi­tals and other health­care facilities.

    In ad­di­tion to the syn-con­fig­u­ra­tion of the imino side chain, com­pared to other third-gen­er­a­tion cephalosporins, the more com­plex moi­ety (con­tain­ing two methyl and a car­boxylic acid group) con­fers extra sta­bil­ity to β-lac­ta­mase en­zymes pro­duced by many Gram-neg­a­tive bac­te­ria. The extra sta­bil­ity to β-lac­ta­mases in­creases the ac­tiv­ity of cef­tazidime against oth­er­wise re­sis­tant Gram-neg­a­tive or­gan­isms in­clud­ing Pseudomonas aeruginosa. The charged pyri­dinium moi­ety in­creases wa­ter-sol­u­bil­ity. Cef­tazidime shares the same vari­able R-group side chain with aztre­onam, a monobac­tam an­tibi­otic; the two drugs share a sim­i­lar spec­trum of ac­tiv­ity, in­clud­ing ac­tiv­ity against Pseudomonas aeruginosa.

  4. Talk:Ceftazidime - Wikipedia › wiki › Talk:Ceftazidime

    From Wikipedia, the free encyclopedia Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ceftazidime.

  5. Ceftazidim - Wikipedia › wiki › Ceftazidim

    Ceftazidima [INN-Spanish], Ceftazidime pentahydrate, Ceftazidime Sodium In Plastic Container, Ceftazidimum [INN-Latin] AHFS/ Monografija. Identifikatori. CAS broj. 78439-06-2. ATC kod. J01 DD02.

    • 546,576
    • C₂₂H₂₂NOS
    • 1,9 h
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  7. Ceftazidime | C22H22N6O7S2 - PubChem › compound › ceftazidime

    Ceftazidime is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin -binding proteins (PBP) located on the inner membrane of the bacterial cell wall.

  8. Ceftazidime - WikEM › wiki › Ceftazidime
    • General
    • Adult Dosing
    • Pediatric Dosing
    • Special Populations
    • Contraindications
    • Adverse Reactions
    • Pharmacology
    • Antibiotic Sensitivities
    Type: Third generation cephalosporin
    Dosage Forms: injectable solution, powder for injection
    Dosage Strengths: injectable solution: 20mg/mL, 40mg/mL; powder for injection: 500mg, 1g, 2g, 6g
    Routes of Administration: IV, IM

    Infections, Bacterial

    1. 1 g IV/IM q8-12h 1.1. Max: 6 g/day

    Pneumonia, Hospital-acquired or ventilator-associated

    1. 2 g IV q8h x7 days

    Infections, Bacterial

    1. Neonates 0-7 days old 1.1. 100 mg/kg/day IM/IV divided q12h 2. Neonates >7 days old, <1200g 2.1. 100mg/kg/day IM/IV divided q12h 3. Neonates >7 days old, >1200g 3.1. 150mg/kg/day IM/IV divided q8h 4. 1mo - 12yo 4.1. 90-150 mg/kg/day IM/IV divided q8h 4.1.1. Max: 6 g/day 4.1.2. Reserve high dose for immunocompromised, cystic fibrosis, or meningitis

    Pregnancy: C; May use during pregnancy
    Lactation: No known risk
    Renal Dosing
    Allergy to class/drug


    1. Seizure 2. Agranulocytosis 3. Thrombocytopenia 4. Anemia, hemolytic 5. Anaphylaxis 6. C. difficile-associated diarrhea


    1. Diarrhea 2. Nausea/Vomiting 3. Abdominal pain 4. Rash 5. Pruritus 6. Urticaria 7. Headache 8. Dizziness 9. ALT, AST elevation 10. BUN, Cr elevation

    Half-life: 1.9h
    Metabolism: Minimal
    Excretion: Urine primarily
    Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis


    1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia

  9. Ceftazidime. Medical search. Wikipedia › en › wikipedia

    ceftazidime. Wikipedia. Medical Information Search. By contrast, the drug efficacy of ceftazidime and piperacillin-tazobactam resulted in similar response rates (61.5% and 63.9 ...

  10. Ceftazidime sodium | C22H21N6NaO7S2 - PubChem › compound › Ceftazidime-sodium

    Ceftazidime Sodium is the sodium salt of ceftazidime, a third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin -binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis.

  11. Oct 12, 2020 · Uses of Ceftazidime: It is used to treat bacterial infections. What do I need to tell my doctor BEFORE I take Ceftazidime? If you have an allergy to ceftazidime or any other part of ceftazidime. If you are allergic to ceftazidime; any part of ceftazidime; or any other drugs, foods, or substances.

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