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From Wikipedia, the free encyclopedia Ceftazidime, sold under the brand names Fortaz among others, is an antibiotic useful for the treatment of a number of bacterial infections.
From Wikipedia, the free encyclopedia Ceftazidime/avibactam,...
- Medical uses
Ceftazidime is used to treat lower respiratory tract, skin,...
- Side effects
Ceftazidime is generally well tolerated. When side effects...
- Medical Uses
- Side Effects
- Mechanism of Action
Ceftazidime is used to treat lower respiratory tract, skin, urinary tract, blood-stream, joint, and abdominal infections, and meningitis. The drug is given intravenously (IV) or intramuscularly (IM) every 8–12 hours (two or three times a day), with dose and frequency varying by the type of infection, severity, and/or renal function of the person. Ceftazidime is also commonly prescribed off-label for nebulization in people with cystic fibrosis for the suppression of Pseudomonas aeruginosain the lungs as well as the treatment of pulmonary exacerbations. Those with kidney disease are dosed less frequently. Ceftazidime is the first-line treatment for the tropical infection, melioidosis, an important cause of sepsis in Asia and Australia. Labeled indications include the treatment of patients with: 1. Pseudomonas aeruginosainfections 2. other Gram-negative, aerobic infections 3. neutropenic fever As a class, cephalosporins hav...
Ceftazidime is generally well tolerated. When side effects occur, they are most commonly local effects from the intravenous line site, allergic reactions, and gastrointestinal symptoms. According to one manufacturer, in clinical trials, allergic reactions including itching, rash, and fever, happened in fewer than 2% of patients. Rare but more serious allergic reactions, such as toxic epidermal necrolysis, Stevens–Johnson syndrome, and erythema multiforme, have been reported with this class of antibiotics, including ceftazidime. Gastrointestinal symptoms, including diarrhea, nausea, vomiting, and abdominal pain, were reported in fewer than 2% of patients. Another source reported, in addition, blood tests of patients may show increased eosinophils (8%), increased lactate dehydrogenase (6%), increased gamma-glutamyl transferase (5%), positive direct Coombs test (4%), increased platelets (thrombo...
Third-generation cephalosporins differ from earlier generations in the presence of a C=N-OCH3 group in their chemical structure (cefuroxime & cefuzonam also bear this functional group but are only listed as class II). This group provides improved stability against certain beta-lactamaseenzymes produced by Gram-negative bacteria. These bacterial enzymes rapidly destroy earlier-generation cephalosporins by breaking open the drug's beta-lactam chemical ring, leading to antibiotic resistance. Though initially active against these bacteria, with widespread use of third-generation cephalosporins, some Gram-negative bacteria that produce extended-spectrum beta-lactamases (ESBLs) are even able to inactivate the third-generation cephalosporins. Infections caused by ESBL-producing Gram-negative bacteria are of particular concern in hospitals and other healthcare facilities.
In addition to the syn-configuration of the imino side chain, compared to other third-generation cephalosporins, the more complex moiety (containing two methyl and a carboxylic acid group) confers extra stability to β-lactamase enzymes produced by many Gram-negative bacteria. The extra stability to β-lactamases increases the activity of ceftazidime against otherwise resistant Gram-negative organisms including Pseudomonas aeruginosa. The charged pyridinium moiety increases water-solubility. Ceftazidime shares the same variable R-group side chain with aztreonam, a monobactam antibiotic; the two drugs share a similar spectrum of activity, including activity against Pseudomonas aeruginosa.
From Wikipedia, the free encyclopedia Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Ceftazidime.
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Ceftazidime is a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin -binding proteins (PBP) located on the inner membrane of the bacterial cell wall.
Type: Third generation cephalosporinDosage Forms: injectable solution, powder for injectionDosage Strengths: injectable solution: 20mg/mL, 40mg/mL; powder for injection: 500mg, 1g, 2g, 6gRoutes of Administration: IV, IM
- Adult Dosing
- Pediatric Dosing
- Special Populations
- Adverse Reactions
- Antibiotic Sensitivities
1. 1 g IV/IM q8-12h 1.1. Max: 6 g/day
Pneumonia, Hospital-acquired or ventilator-associated
1. 2 g IV q8h x7 days
1. Neonates 0-7 days old 1.1. 100 mg/kg/day IM/IV divided q12h 2. Neonates >7 days old, <1200g 2.1. 100mg/kg/day IM/IV divided q12h 3. Neonates >7 days old, >1200g 3.1. 150mg/kg/day IM/IV divided q8h 4. 1mo - 12yo 4.1. 90-150 mg/kg/day IM/IV divided q8h 4.1.1. Max: 6 g/day 4.1.2. Reserve high dose for immunocompromised, cystic fibrosis, or meningitisPregnancy: C; May use during pregnancyLactation: No known riskRenal DosingAllergy to class/drugCaution:
1. Seizure 2. Agranulocytosis 3. Thrombocytopenia 4. Anemia, hemolytic 5. Anaphylaxis 6. C. difficile-associated diarrhea
1. Diarrhea 2. Nausea/Vomiting 3. Abdominal pain 4. Rash 5. Pruritus 6. Urticaria 7. Headache 8. Dizziness 9. ALT, AST elevation 10. BUN, Cr elevationHalf-life: 1.9hMetabolism: MinimalExcretion: Urine primarilyMechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis
1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia
ceftazidime. Wikipedia. Medical Information Search. By contrast, the drug efficacy of ceftazidime and piperacillin-tazobactam resulted in similar response rates (61.5% and 63.9 ...
Ceftazidime Sodium is the sodium salt of ceftazidime, a third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin -binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis.
Oct 12, 2020 · Uses of Ceftazidime: It is used to treat bacterial infections. What do I need to tell my doctor BEFORE I take Ceftazidime? If you have an allergy to ceftazidime or any other part of ceftazidime. If you are allergic to ceftazidime; any part of ceftazidime; or any other drugs, foods, or substances.