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Primary target of neutralizing antibodies
- The DENV E protein is the primary target of neutralizing antibodies, which has led to a large body of work to assess the immunogenicity and efficacy of this protein as a subunit vaccine (10, 13, 14).
www.science.org › doi › 10Designed, highly expressing, thermostable dengue virus 2 ...
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Nov 25, 2011 · Most dengue-specific antibodies in human immune sera are weakly neutralizing and bind to multiple DENV serotypes. The human antibodies that potently and type specifically neutralize DENV represent a small fraction of the total DENV-specific antibody response.
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Dengue viruses (DENV) are the causative agents of dengue...
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- Human Dengue Antibodies Against Structural and Nonstructural Proteins
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As two MAbs (DV2-48 and DV2-67) recognized a determinant on...
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Dengue virus (DEN) is a mosquito-borne virus belonging to...
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Jan 20, 2024 · It is known that DENV infection does not elicit many neutralizing antibodies targeting EDIII 60, and that potent DENV neutralizing antibodies rather recognize complex epitopes formed by E...
Jan 9, 2024 · High cross-reactive neutralizing antibody titer is associated with protection from dengue disease in participants who have experienced a single prior DENV infection, but not in those who have...
- Sandra Bos
Jun 2, 2023 · Despite that, many neutralizing antibodies have been identified against the DENV, which are thought to be useful in reducing dengue severity. Indeed, an antibody must be free from ADE for therapeutic application, as it is pretty common in dengue infection and escalates disease severity.
- 10.3389/fimmu.2023.1200195
- 2023
- Front Immunol. 2023; 14: 1200195.
antibody can eliminate DENV so quickly that the person does not become noticeably ill. If a person has a second DENV infection with a new DENV type, the primary response is to make -reactive antigens to the first DENV type. This process is called original antigenic sin. Memory B cells are responsible for the production of these heterotypic ...
Oct 10, 2018 · DENV will exploit the autophagy pathway and use autophagosomes for replication, assembly and maturation, and evasion of neutralizing antibodies during transmission (red) Furthermore, along with inhibiting IFNα/β production, NS proteins block the IFNAR pathways.
Oct 15, 2021 · Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein homodimers. However, recombinantly expressed soluble E proteins are monomers under vaccination conditions and do not present these quaternary epitopes, partly explaining their limited success as vaccine antigens.
