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  1. From Wikipedia, the free encyclopedia Gentamicin, sold under brand name Garamycin among others, is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others.

    Gentamicin - Wikipedia

    https://en.wikipedia.org/wiki/Gentamicin
  2. Gentamicin - Wikipedia

    en.wikipedia.org › wiki › Gentamicin

    From Wikipedia, the free encyclopedia Gentamicin, sold under brand name Garamycin among others, is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others.

    • C₂₁H₄₃N₅O₇
    • Cidomycin, Genticyn, Garamycin, others
  3. Gentamicin - Wikipedia

    sh.wikipedia.org › wiki › Gentamicin

    Gentamicin je antibiotik iz porodice aminoglikozida i deluje na veliki broj bakterijskih infekcija, naročito na infekcije izazvane Gram negativnim bakterijama. Gentamicin je mimetik prirodnih biomolekula i nadoveže se na bakterijske ribozome gde dovodi do nepravilnog čitanja genetičkog koda .

    • ograničena oralna biodostupnost
    • 0-10%
    • 477.596 g/mol
    • C₂₁H₄₃NO
  4. Gentamicin - Wikipedia

    bs.wikipedia.org › wiki › Gentamicin

    Gentamicin je antibiotik iz grupe aminoglikozida koji djeluje na veliki broj bakterijskih infekcija, osobito na infekcije izazvane gram-negativnim bakterijama. Gentamicin djeluje oponašajući prirodne biomolekule što mu omogućuje vezivanje na bakterijske ribosome i dovodi do nepravilnog čitanja genetskog koda.

  5. Gentamicin – Wikipedija

    hr.wikipedia.org › wiki › Gentamicin

    Gentamicin je antibiotik iz skupine aminoglikozida koji djeluje na velik broj bakterijskih infekcija, osobito na infekcije izazvane gram-negativnim bakterijama.. Gentamicin djeluje oponašajući prirodne biomolekule što mu omogućuje vezivanje na bakterijske ribosome i dovodi do nepravilnog čitanja genetskog koda.

  6. Talk:Gentamicin - Wikipedia

    en.wikipedia.org › wiki › Talk:Gentamicin
    • Topical Inclusion
    • Merger Proposal
    • Disappointed
    • Deafness
    • Wrong Structure
    • Gentamicin Inner Ear Side Effects Caused by Drops to The eye?
    • Relevance as A Cystic Fibrosis Treatment?
    • Orientation of The Two Structure Diagrams
    • CP133 Focus Edits
    • CP133 Peer Review

    Gentamicin can also be used topically, but this use is not mentioned in the article. — Preceding unsigned comment added by Niqueco (talk • contribs) 00:33, 21 August 2005 (UTC) Done. Should I take out the sign? I only added two words... 84.42.146.4403:12, 1 September 2005 (UTC) i think somone should remove the link for "wobblers anonymous" from the side effects, and possibly put it into another paragraph - i rekon it is out of context in that part of the article —Preceding unsigned comment added by 80.192.146.160 (talk) 16:27, 24 June 2008 (UTC) Would this Wiki be an appropriate place to comment on the reason this drug is spelled "-mIcin" instead of "-mYcin" as is the case with many other antibiotics, including the other aminoglycoside agents? I realize this is somewhat trivial, but this is often a source of frustration when clinicians try to search for "gentamycin" and are not successful because they don't realize that this is not the correct spelling. (I actually don't the reason...

    I've proposed that the page Gentamicin toxicity be merged into the "side effects" section of this page. Any discussion? Agathman (talk) 22:21, 13 April 2009 (UTC) do it Mba123 (talk) 19:06, 17 May 2009 (UTC) good idea! --Kischel (talk) 13:58, 4 August 2009 (UTC) Definitely, ASAP. --Cpt ricard (talk) 18:56, 28 November 2009 (UTC) I've merged the two, and now for some clean-up --Cpt ricard (talk) 19:18, 28 November 2009 (UTC)

    While this page isn't terrible, particularly by general wiki standards, compared to most other medications on here this page is really lacking. The side effects take up more than half of the article! I might be able to make some additions at some point, but it is definately in need of some work.McPat (talk) 13:40, 7 July 2009 (UTC)

    The article does mention "ototoxic", but it would be good to use language known to the layman, such as "deaf". —Preceding unsigned comment added by 134.134.139.72 (talk) 20:06, 20 December 2010 (UTC)

    The schematic structure given at the top is missing a N-methyl substitution (compare it with the ball and stick model which is correct). The C6-N is a secondary amine. It is the amine to the right in the schematic structure. Would someone be able to fix this? Silasmellor (talk) 11:20, 18 June 2011 (UTC) 1. Someone should fix the structures. But looking up the CAS registry number here, it says that it is actually not a pure substance but a mixture of 3 similar compounds, and that's also mentioned on ChemIDplus. Icek (talk) 12:30, 20 September 2013 (UTC)

    Apologies if this not the appropriate place to ask this question, but the first paragraph of the side effects section deals extensively with side effects to the inner ear, yet the last sentence reads "these side effects are most common when the drug is administered via drops directly to the eye"; should that not read "these side effects are most common when the drug is administered via drops directly to the ear"?Oreeric (talk) 02:44, 3 July 2012 (UTC)

    Can someone contribute a section on Gentamicin's possible use as a treatment for some variants of Cystic Fibrosis (and one for Duchenne Muscular Dystrophy too)? I lack the knowledge and expertise to do so :( AncientBrit (talk) 04:19, 22 December 2012 (UTC)

    I'm an interested lay-person and often have trouble matching the chemical structure pic with the ball-picture. In this case it seems the one is the mirror (mirrored on a vertical axis) of the other. Can someone fix this?And is it too much to ask if someone who is a bit more proficient editing wikipedia to do this for any other pages they might come across? I'm sure I'm not the only one for whom this is an admittedly minor problem.Thanks, j.appelzaad 15:56, 13 March 2014 UTC — Preceding unsigned comment added by 87.211.115.30 (talk)

    We focused on adding a contraindications and special populations section to the page. These are important points regarding the medication, and it is good knowledge to know in which people it can be used safely or not. It is also a helpful guide for professionals in the healthcare field to know when not to use gentamicin. Our main focus for this paper included organizing it a little better and providing more information that we deemed useful to the general public. Rg cp133 g12 (talk) 04:15, 5 November 2015 (UTC) Overall, for most of the sections, our group focused on the references and tried to add/strengthen the resources used by previous editors. We selected three areas: introduction, medical uses, and side effects and went through each sentence to make sure they all have good references attached to them. Additionally, we also added sections such as contraindication and special populations because we thought the public would find those information beneficialRg cp133 g12 (talk) 04:2...

    Yes, this draft submission reflects a neutral point of view and points included were verifiable with cited published material.Some areas of improvement include: 1. Introduction: Try to include some common side effects along with serious side effects. 2. Side effects: Try adding specific information such as percentages if available regarding how likely the side effects will occur (similar to nephrotoxicity and ototoxicity). 3. Side effect – nephrotoxicity: Listing symptoms of kidney damage that patients can easily distinguish at home would be helpful. 4. Contraindications: List out a few examples of the type of hypersensitivity or the serious toxic reaction to look for. Echung11 (talk) 06:05, 9 November 2015 (UTC) This draft is unbiased, neutral, and well written with a lot of cited published sources.Recommendations for improvement: 1. maybe also use bullet appoints for the other "less common" side effects and how frequent the incidence is 2. maybe add use in hepatic/renal impairment...

  7. Gentamicină - Wikipedia

    ro.wikipedia.org › wiki › Gentamicină

    De la Wikipedia, enciclopedia liberă Gentamicina este un medicament antibiotic din clasa aminoglicozidelor, utilizat în tratamentul unor infecții bacteriene. Printre acestea se numără infecțiile osoase, endocarditele, boala inflamatorie pelviană, meningitele, pneumonia, infecțiile de tract urinar și septicemia.

    • 3.3K
    • 1403-66-3
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  8. Gentamicin – Wikipedia tiếng Việt

    vi.wikipedia.org › wiki › Gentamicin

    Gentamicin Bách khoa toàn thư mở Wikipedia Gentamicin, được bán dưới tên thương hiệu Garamycin cùng với một số các tên khác, là một loại kháng sinh được sử dụng để điều trị một số loại nhiễm khuẩn.

    • tiêm tĩnh mạch, tiêm cơ, thuốc bôi
    • AU: D, US: D (Bằng chứng về rủi ro)
  9. Gentamicin - WikEM

    www.wikem.org › wiki › Gentamicin
    • General
    • Adult Dosing
    • Special Populations
    • Pharmacology
    • Antibiotic Sensitivities
    Type: Aminoglycosides
    Dosage Forms: IM; IV
    Common Trade Names:
    All: If obese, use Adjusted Weight = IBW + 0.4 x (ABW - IBW)
    All: Adjust repeat dosing based on levels
    Lactation: Probably safe
    Renal Dosing
    Hepatic Dosing (Adult & Pediatric)
    Half-life:
    Metabolism:
    Excretion:
    Mechanism of Action:

    Key

    1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia

  10. Gentamicin/betamethasone valerate/clotrimazoleis a fixed dose combination veterinary drug, sold under the trade name Otomax. It is a suspension for oticuse in dogs. The active ingredients are gentamicin, betamethasone valerateand clotrimazole. This drug product is used for treatment of acute external otitis.

  11. ゲンタマイシン - Wikipedia

    ja.wikipedia.org › wiki › ゲンタマイシン
    • 作用機序
    • 臨床応用
    • 副作用

    ゲンタマイシンは殺菌性の抗生物質で、細菌のリボソーム30S サブユニットに結合して、蛋白合成を阻害する。 他のアミノグリコシド系抗生物質と同様経口投与では無効である。これは、小腸にて吸収された後、門脈を経由して肝臓に到達し、不活化されるためである。そのため、静脈注射、筋肉注射、局所投与。および、軟膏による皮膚への塗布にて利用される。

    ゲンタマイシンは、グラム陰性桿菌による感染症にほぼ専門的に用いられる。殺菌能の高い薬剤で、緑膿菌などの日和見感染症の起炎菌による敗血症に対する効果が高い。また、広範囲の薬剤が無効である腸球菌に対しても、ペニシリン系薬剤と併用することによって相乗効果を発揮する。緑膿菌のほか、大腸菌、インフルエンザ桿菌、クレブシエラ菌、セラチア菌、アシネトバクター、シトロバクター、エンテロバクターなど血液感染の原因となるようなグラム陰性桿菌はほぼ網羅する抗菌スペクトラムを有する。ゲンタマイシンは黄色ブドウ球菌などのグラム陽性菌や、淋菌・髄膜炎菌 のようなグラム陰性球菌、またレジオネラ菌 による感染症には効果がない。アミノグリコシド系抗生物質には、他の抗生物質に比較すると非常に耐性化しにくいという特徴がある。よく似たトブラマイシンとは、ゲンタマイシンが緑膿菌を得意とするに対し、トブラマイシンはセラチア菌により活性が高いという違いが知られている(どちらもよく効く)。緑膿菌に対しては、有効性、また耐性化の予防の観点から、かならずセフタジジムなど他の抗緑膿菌活性を持った薬剤との併用が行われる。 敗血症のほかは、腎盂腎炎に主に用いられる。組織移行性が低いので、肺炎などといった主要臓器の感染症に用いられることは少ないが、上記の日和見感染症に対する効果を期待し用いることはある。一方血液脳関門を通過できないため、静脈注射では、髄膜炎には完全に無効である。髄腔内投与を行う場合もあるが、この効果を積極的に支持する科学的根拠はない。また、軟膏製剤もあるが、この使用を正当化するような科学的根拠も乏しい。

    すべてのアミノグリコシド系抗生物質は耳に対し毒性を持つ。前庭神経に対する毒性は平衡感覚障害をきたし、一方蝸牛神経に対する障害は聴覚障害をおこし、まれに聾にいたる。アミノグリコシドの中で、ゲンタマイシンの聴覚毒性は最も強い。聴覚障害は、薬剤中止によってもあまり改善しない。 ゲンタマイシンは高い腎毒性をもち、場合によっては急性腎不全に至ることがある。腎障害は、薬剤中止によって改善することが多い。腎毒性の発症頻度は、ゲンタマイシンの血中最低濃度(トラフ)と相関する。腎障害を予防するため、体重により投与量を調節する。欧米では、ゲンタマイシンの投与量の計算式があるが、日本の保険医療の範囲内でこれに従うことは、よほど体が小さくない限り難しい(投与量が上限をこえてしまう[要出典])。治療中は血清中のゲンタマイシン濃度を監視する。

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