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A prodrug is a chemical compound that, after administration, is metabolized (i.e. converted within the body) into a pharmacologically active substance.[1] Inactive prodrugs are pharmacologically inactive compounds that are metabolized into an active form within the body. Instead of administering a drug directly, a corresponding prodrug might be used instead to improve how a medicine is ...
The full name of the chemical is 2,5-dimethoxy-4-bromoamphetamine. DOB has a stereocenter and R - (−)-DOB is the eutomer. This is an important finding as it is suggestive that it is targeting different receptors relative to most other phenethylamines (e.g. MDMA) where the R -isomer serves as the distomer. The toxicity of DOB is not fully ...
- C₁₁H₁₆BrNO₂
- 63 to 65 °C (145 to 149 °F; 336 to 338 K), (207–208 °C hydrochloride)
- 274.15 g/mol
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Oct 25, 2021 · A prodrug is an inactive medication, but once it enters the body, the body turns it into an active form so that the medication can have its intended effect. This article will provide a definition of a prodrug, examples, and explain its use in medicine. Learn more about prodrugs with GoodRx.
Prodrug. A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted ...
Mar 16, 2018 · Introduction. Prodrug is a pharmacologically inactive derivative of an active drug and undergoes in vivo biotransformation to release the active drug by chemical or enzymatic cleavages.[1,2,3] A prodrug strategy is typically used when a pharmacologically active drug has poor solubility or permeability.[1,2] Various chemically or enzymatically labile functional groups have been introduced to ...
- Seungil Cho, Young-Ran Yoon
- 10.12793/tcp.2018.26.1.1
- 2018
- Transl Clin Pharmacol. 2018 Mar; 26(1): 1-5.
a | The drug–promoiety is the prodrug that is typically pharmacologically inactive. In broad terms, the barrier can be thought of as any liability or limitation of a parent drug that prevents ...
Feb 17, 2020 · Evofosfamide. Evofosfamide, also known as TH-302 ( Figure 3) is a hypoxia-activated prodrug of brominated isophosphoramide mustrd. The active form is a potent DNA alkylator. TH-302 is being tested for efficacy in a variety of cancers such as pancreatic, oesophageal, soft tissue sarcoma, and solid tumors.
