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1. • • Early investigations demonstrated that erythromycin increased gastrointestinal motility, and more recent studies suggest that it fortuitously binds to and stimulates the receptor for the gastrointestinal peptide motilin.
     Reference:

     Erythromycin: a motilin agonist and gastrointestinal ... - PubMed

2. pubmed.ncbi.nlm.nih.gov › 8470625Erythromycin: a motilin agonist and gastrointestinal ... - PubMed

   pubmed.ncbi.nlm.nih.gov › 8470625

   Early investigations demonstrated that erythromycin increased gastrointestinal motility, and more recent studies suggest that it fortuitously binds to and stimulates the receptor for the gastrointestinal peptide motilin.

   • Motilin: towards a new understanding of the gastrointestinal ...

     Erythromycin: clinical use as a motilin receptor agonist....

   • Erythromycin is a motilin receptor agonist - PubMed

     Erythromycin A (EMA) is a potent stimulator of...

3. People also ask

   Is erythromycin a motilin receptor agonist?

   • Peeters, T. et al. Erythromycin is a motilin receptor agonist. Am. J. Physiol. 257, G470–G474 (1989). Depoortere, I. et al. Structure-activity relation of erythromycin-related macrolides in inducing contractions and in displacing bound motilin in rabbit duodenum. Neurogastroenterol. Motil. 1, 150–159 (1989). Tack, J. & Peeters, T.

   Motilin: from gastric motility stimulation to hunger signalling

   www.nature.com/articles/s41574-019-0155-0

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   Does erythromycin increase gastrointestinal motility?

   • This follows a decade of research into the mechanism of well-recognized gastrointestinal side effects of erythromycin. Early investigations demonstrated that erythromycin increased gastrointestinal motility, and more recent studies suggest that it fortuitously binds to and stimulates the receptor for the gastrointestinal peptide motilin.

   Erythromycin: a motilin agonist and gastrointestinal prokinetic agent

   pubmed.ncbi.nlm.nih.gov/8470625/

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   Does erythromycin release motilin?

   • The stimulus for motilin release is unknown. Erythromycin is a highly potent motilin agonist that increases the amplitude and frequency of antral contractions and initiates gastric phase III contractions. This effect is attributable to the 14-member ring structure of a family of compounds referred to as macrolides.

   Motility-modifying agents and management of disorders of

   www.gastrojournal.org/article/S0016-5085(00)70005-9/fulltext

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   Does erythromycin mimic motilin?

   • Luiking, Y. C. et al. Motilin induces gall bladder emptying and antral contractions in the fasted state in humans. Gut 42, 830–835 (1998). Itoh, Z., Nakaya, M., Suzuki, T., Arai, H. & Wakabayashi, K. Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog. Am. J. Physiol. 247, G688–G694 (1984).

   Motilin: from gastric motility stimulation to hunger signalling

   www.nature.com/articles/s41574-019-0155-0

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4. www.ncbi.nlm.nih.gov › pmc › articlesMotilin: towards a new understanding of the gastrointestinal ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 14, 2013 · Erythromycin: clinical use as a motilin receptor agonist. Erythromycin is used to induce rapid intubation or endoscopy, remove gastric contents prior to endoscopy or surgery (Levy et al., 2004; Carbonell et al., 2006), treat patients with gastroparesis (DiBaise and Quigley, 1999; Maganti et al., 2003; Ritz et al., 2005) or chronic intestinal ...

   • Author: G J Sanger, Y Wang, A Hobson, J Broad
   • DOI: 10.1111/bph.12075

   • Publish Year: 2013
   • Publication: Br J Pharmacol. 2013 Dec; 170(7): 1323-1332.

5. www.nature.com › articles › s41574/019/0155-0Motilin: from gastric motility stimulation to hunger ... - Nature

   www.nature.com › articles › s41574/019/0155-0

   Jan 23, 2019 · In 1989, erythromycin A was identified 8 as a motilin receptor agonist. Erythromycin A belongs to the class of macrolides, a group of molecules consisting of different lactone ring sizes...

   • Author: Eveline Deloose, Wout Verbeure, Inge Depoortere, Jan Tack

   • Publish Year: 2019

6. www.ncbi.nlm.nih.gov › books › NBK532249Erythromycin - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK532249

   Jul 2, 2023 · The erythromycin cannot bind to the ribosome, and the bacteria can continue protein synthesis. Aside from being a bacteriostatic macrolide antibiotic, erythromycin is a pro-motility drug. It is an agonist to motilin, which increases motility in the gut. Pharmacokinetics

   • Published: 2023/07/02

7. www.gastrojournal.org › article › S0016-5085(00Motility-modifying agents and management of disorders of ...

   www.gastrojournal.org › article › S0016-5085(00

   For example, erythromycin acting as a motilin agonist initiates MMCs, and recent evidence suggests that baclofen, a γ-aminobutyric (GABA) B agonist, specifically inhibits tLESRs.

   • Author: John E. Pandolfino, Colin W. Howden, Peter J. Kahrilas

   • Publish Year: 2000

8. pubmed.ncbi.nlm.nih.gov › 2782416Erythromycin is a motilin receptor agonist - PubMed

   pubmed.ncbi.nlm.nih.gov › 2782416

   Erythromycin A (EMA) is a potent stimulator of gastrointestinal motor activity. In vitro studies suggest that it mimics motilin, a peptide that stimulates motor activity in human and in rabbit via smooth muscle receptors.

9. en.wikipedia.org › wiki › ErythromycinErythromycin - Wikipedia

   en.wikipedia.org › wiki › Erythromycin

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   Erythromycin increases gut motility by binding to motilin receptor, thus it is a motilin receptor agonist in addition to its antimicrobial properties. It can be therefore administered intravenously as a stomach emptying stimulant.