Search results
People also ask
What are penicillin-binding proteins (PBPs)?
How do penicillin-binding proteins bind glycan strands?
Are penicillin-binding proteins a target for -lactam antibiotics?
How long have penicillin-binding proteins been studied?
Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent of many bacteria ; the name just reflects the way by which the protein was discovered.
- Beta-lactam antibiotics
The final transpeptidation step in the synthesis of the...
- Penicillin
Penicillin and other β-lactam antibiotics act by inhibiting...
- Beta-lactam antibiotics
Penicillin and other β-lactam antibiotics act by inhibiting penicillin-binding proteins, which normally catalyze cross-linking of bacterial cell walls. Penicillin kills bacteria by inhibiting the completion of the synthesis of peptidoglycans , the structural component of the bacterial cell wall .
- Between 0.5 and 56 hours
- Liver
- In general: ℞ (Prescription only)
The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by DD-transpeptidases, also known as penicillin binding proteins (PBPs). PBPs vary in their affinity for penicillin and other β-lactam antibiotics. The number of PBPs varies between bacterial species.
- Bacterial infection
- Penicillin binding protein
Penicillin-binding proteins (PBPs) are a family of bacterial enzymes responsible for the synthesis of PG via the polymerization of the glycan chain (transglycosylation) and the cross-linking of peptide chains (transpeptidation).
May 18, 2022 · Bla1 binds and retains labelled [H 3]-benzylpenicillin in contrast to the efficient release of the hydrolyzed penicillin by other bacterial β-lactamases; this behavior correlates with a low penicillin deacylation rate and suggests that this enzyme has some properties of penicillin-binding proteins that are known to retain the bound penicillin ...
- 10.3390/ijms23105662
- 2022/05
- Int J Mol Sci. 2022 May; 23(10): 5662.
Feb 24, 2017 · Penicillin-binding proteins (PBPs) are bacterial proteins that bind to penicillin and other antibiotics of the β-lactam class. Penicillin-binding proteins are generally enzymes involved...
Sep 1, 2006 · Penicillin-binding proteins (PBPs), membrane-associated macromolecules which play key roles in the cell wall synthesis process, have been exploited for over 70 years as the targets of the highly successful β-lactam antibiotics.
