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The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron ...
The serotonin transporter is responsible for terminating the action of serotonin in the extracellular space through the energy dependent reuptake of serotonin into the presynaptic terminal. Thus, the serotonin transporter plays a key role in regulating serotonergic neurotransmission.
Jul 28, 2016 · Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release. Another aspect of their function, however, may be to generate currents large enough to have physiological consequences.
- Louis J. De Felice
- 2016
Nov 4, 2019 · Abstract. Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4 ...
- Gary Rudnick, Walter Sandtner
- 10.1085/jgp.201812066
- 2019
- 2019/11/11
Oct 5, 2022 · The highly selective serotonin transporter (SERT), which is located on the presynaptic membrane, functions to remove serotonin from the synaptic cleft. Once transported into the presynaptic neuron, serotonin is recycled back into presynaptic vesicles, where it is protected from metabolism.
Apr 11, 2019 · The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the...
