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    • What is IARC? – Food Insight
      • No, the IARC classification is a Hazard Identification determination only, the first step in the risk assessment process. IARC does not engage in risk assessments, so the IARC classifications do not mean that consuming a food containing those compounds will cause cancer in humans. Additional IFIC Resources on IARC:
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    What is hazard identification and risk assessment?

    Does the IARC classification mean that food containing carcinogens is safe?

    What is IARC and why does it matter?

    How do you determine if a chemical is hazardous?

  2. Oct 19, 2020 · No, the IARC classification is a Hazard Identification determination only, the first step in the risk assessment process. IARC does not engage in risk assessments, so the IARC classifications do not mean that consuming a food containing those compounds will cause cancer in humans. Additional IFIC Resources on IARC:

  3. hazard identification and to also consider their utility for QRC. As a general principle, if resources allow, preparatory work by IARC staff or individual members of the Working Group could be conducted and presented in the orking W Group meeting. For example, if the literature sufficient, a metawere -analysis might be conducted to

    • Table of Contents
    • Overview
    • I. Introduction
    • II. The Hazard Determination Process
    • III. Selection of Chemicals
    • IV. Data Collection
    • v. Data Analysis
    • VI. Documentation
    • Appendix A Glossary of Terms and Definitions
    • Appendix B Information Sources to Assist with Hazard Determination

    OVERVIEW 1. INTRODUCTION What is Hazard Determination? Who Must Conduct Hazard Determinations? What Resources are Needed to Conduct a Hazard Determination? How Should This Guidance Document be Used? 2. THE HAZARD DETERMINATION PROCESS What is the HCS Definition of a "Chemical"? How Will I Know if My Chemical is "Hazardous"? Is Hazard Determination the Same for Mixtures as for Individual Elements and Compounds? What is Involved in Conducting a Hazard Determination? 3. SELECTION OF CHEMICALS 4. DATA COLLECTION Physical and Chemical Properties Health Effects 5. DATA ANALYSIS Physical Hazards Fire Hazards Explosive Hazards Reactive Hazards Health Hazards Systemic Effects Target Organ Effects 6. DOCUMENTATION Chemical Inventory Description of Procedures Used for Hazard Determination Specific Data Retrieved for Each Chemical APPENDICES 1. Glossary of Terms and Definitions 2. Information Sources to Assist with Hazard Determination 3. Materials Regulated by OSHA as Toxic and Hazardous Subst...

    This document is designed to help manufacturers and importers of chemicals identify chemical hazards so that employees and downstream users can be informed about these hazards as required by the Occupational Safety and Health Administration's (OSHA) Hazard Communication standard. This guidance may also be useful to employers who decide to conduct hazard determinations in order to assure the accuracy and completeness of information provided to them by suppliers. Hazard determination is the critically important first stage in the process of establishing an effective hazard communication program. The process of hazard determination consists of four basic steps. These are: 1. Selection of chemicals to evaluate; 2. Collection of data; 3. Analysis of the collected data; and 4. Documentation of the hazard determination process and the results obtained. This document provides guidance as to the processes involved and identifies considerations in the conduct of hazard determinations. Since m...

    OSHA's Hazard Communication standard (HCS) is designed to protect against chemical source illnesses and injuries by ensuring that employers and employees are provided with sufficient information to anticipate, recognize, evaluate and control chemical hazards and take appropriate protective measures. This information is provided through material safety data sheets (MSDSs), labels, and employee training. In order for MSDSs, labels, and training to be effective, the hazard information they convey must be complete and accurate. Thus, it is critically important to obtain comprehensive and correct information about the hazards associated with particular chemicals. What is Hazard Determination? Hazard determination is the process of evaluating available scientific evidence in order to determine if a chemical is hazardous pursuant to the HCS. This evaluation identifies both physical hazards (e.g. , flammability or reactivity) and health hazards (e.g. , carcinogenicity or sensitization). The...

    What is the HCS Definition of a "Chemical"? The definition of a chemical in the HCS is much broader than that which is commonly used. The HCS definition of chemical is "any element, chemical compound, or mixture of elements and/or compounds. " Thus, virtually any product is a "chemical. " These various types of chemicals are as follows: 1. Element- the simplest form of matter. There are currently 109 known elements in the periodic table. Examples of elements are aluminum, carbon, chlorine, hydrogen, mercury and oxygen. 2. Chemical compound- a substance consisting of two or more elements combined or bonded together so that its constituent elements are always present in the same proportions. 3. Mixture- any combination of two or more chemicals if the combination is not, in whole or in part, the result of a chemical reaction. Although virtually all materials are considered chemicals under this definition, the HCS identifies certain categories of chemicals that are not covered by the st...

    The ultimate goal in the hazard determination process is to know and document the hazards of all covered chemicals you manufacture or import. In order to achieve this you must first determine which chemicals require a hazard determination. The logical way to do this is to first prepare an inventory of all chemicals manufactured or imported. Items exempted from coverage under the HCS may be excluded from the inventory. For chemicals obtained from suppliers, you may rely upon the MSDSs and labels provided by the chemical manufacturer or importer. However, you may choose to conduct hazard determinations for those chemicals if you are concerned about the adequacy of the hazard information you have received. If a chemical inventory is not already in place, a good start would be to review purchase orders and receipts to create an initial inventory. Next, the workplace should be inspected to identify any additional chemicals present. It would be ideal to note the location and quantity of e...

    The second step in the hazard determination process is data collection. There are two main questions to be answered: 1) what type of data should be searched for and collected; and 2) how do I go about finding sources that might contain the desired data? You should recognize that the hazard determination process involves the identification of all of the hazards associated with a chemical, not just some of them. This process must be completed even though some data elements may be difficult to locate. Any hazard that exists for the chemical must be identified and communicated to downstream employers and employees. To complete the hazard identification, information is needed in three categories: 1. chemical identity; 2. chemical and physical properties; and 3. health effects. There are numerous sources that could be searched for this information. A list of commonly used data sources is provided in Appendix B, although other sources exist and new sources continue to appear online and in...

    The third step in the hazard determination process is data analysis. This step is the most demanding in terms of technical expertise. The HCS requires that chemical manufacturers and importers conduct a hazard determination to determine whether physical or health hazards exist. In some cases, especially for physical hazards, a definition in the HCS establishes the criteria to be followed. For example, if a liquid has a flashpoint below 100ºF, it is by definition a "flammable liquid". This type of procedure is a simple data analysis. You can look up the flashpoint in a standard reference and accept it at face value. In the event that your company is manufacturing or importing a chemical for which there is no information on the flashpoint, you may choose to determine the flashpoint by laboratory testing, but testing is not required by the HCS. As a rule, the HCS attempts to minimize the burden of literature search and review while satisfying the need to provide information required to...

    The fourth and final step in the hazard determination processis very important. All the other steps will be wasted if you do not document your findings carefully. If a chemical is found to be hazardous, it is recommended that the findings be documented in order to assist in preparing labels and MSDSs, and to maintain a record for future reference and updating. In addition, the HCS requires data documentation of the hazard determination as follows: Chemical manufacturers, importers, or employers evaluating chemicals shall describe in writing the procedures they use to determine the hazards of the chemical they evaluate. The written procedures are to be made available, upon request, to employees, their designated representatives, the Assistant Secretary and the Director [OSHA and NIOSH officials]. The written description may be incorporated into the written hazard communication program required under paragraph (e) of this section [the HCS]. To meet the HCS requirements, it is recommen...

    The following glossary presents brief explanations of acronyms and common terms used in this document. Absorbed Dose. The amount of a substance that actually enters into the body, usually expressed as milligrams of substance per kilogram of body weight (mg/kg). ACGIH. The American Conference of Governmental Industrial Hygienists is an organization of government and academic professionals engaged in occupational safety and health programs. ACGIH establishes recommended occupational exposure limits for chemical substances and physical agents known as Threshold Limit Values; see TLV. Acid. A compound that undergoes dissociation in water with the formation of hydrogen ions. Acids have pH values below 7 and will neutralize bases or alkaline media. Acids will react with bases to form salts. Acids have a sour taste and with a pH in the 0 to 2 range cause severe skin and eye burns. Acute Dose. The amount of a substance administered or received over a very short period of time (minutes or ho...

    This compilation is not intended to be a complete listing of the many literature sources and computerized databases that include information on the physical/chemical and health hazards of chemical substances. Researchers should conduct their own literature search and use the most recent editions of the literature, even though a date is provided in this list for some books and documents. Documents and Books: I. Sources for Specific Chemical Data: A Comprehensive Guide to the Hazardous Properties of Chemical Substances, 2nd Edition. Pradyot Patnaik. Wiley & Sons, New York. 1999. A Guide to Hazardous Materials Management. Physical Characteristics, Federal Regulations, and Response Alternatives. Aileen Schumacher. Greenwood Press, Westport, CT. 1988. A Guide to OSHA Regulations on Storing and Handling Flammable and Combustible Liquids. Matthew M. Carmel. 1991. ATSDR's Toxicological Profiles 2004 on CD-ROM. U.S. Public Health Service, Atlanta, Georgia, USA. 2005. Bretherick's Handbook of...

  4. Hazard identification, including carcinogenic potential, is an important component in the determination of the potential human health risk of a pesticide. The determination of such risk, however, is not solely driven by the hazard profile but is also a function of the potential exposure to the pesticide.

  5. The HCS defines hazard class as the nature of a physical or health hazard, e.g., flammable solid, carcinogen, and acute toxicity. Hazard category means the division of criteria within each hazard class, e.g., acute toxicity and flammable liquids each include four hazard categories numbered from category 1 through category 4.

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