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Recombination: A process in which the genomes of two SARS-CoV-2 variants combine during the viral replication process to form a new variant that is different from both parent lineages. This may occur when a person is infected with two variants at the same time. The lineage that results from recombination is called a “recombinant.”.
Mar 27, 2024 · It remains critical that global systems to detect signals of potential variants of interest (VOIs) or variants of concern (VOCs) and rapidly assess the risk posed by SARS-CoV-2 variants to public health are maintained, and data are shared, according to good principles and in a timely fashion.
The term variant of concern ( VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
Feb 6, 2023 · No matter the variant, a surge in cases can impact healthcare resources. Even if an infection caused by a particular variant is less likely to cause severe disease compared to other variants, an increase in the total number of cases could cause an increase in hospitalizations, put more strain on healthcare resources, and potentially lead to ...
Sep 1, 2023 · Alpha (B.1.1.7) was the first of the highly publicized variants. Alpha first appeared in Great Britain in November 2020 and infections surged in December of that year. It soon surfaced around the world and became the dominant variant in the U.S., where the CDC classified it as a variant of concern.
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Nov 20, 2023 · A Variant of Concern (VOC) is a term that describes a SARS-CoV-2 variant that meets the definition of a VOI (see above), but also meets at least one of the following criteria when compared with other variants: it can cause a detrimental change in disease severity
Apr 8, 2022 · These variants are more likely to cause severe disease, evade diagnostic tests, or resist antiviral treatment. Alpha, beta, gamma, delta and omicron variants of the SARS-CoV-2 coronavirus are classified as variants of concern. A variant of high consequence is a variant for which current vaccines do not offer protection. As of now, there are no ...
