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An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Dec 8, 2022 · Arylcyclohexylamine (ACH) derivatives, such as ketamine, are of particular concern, given their rapidly increasing use and the absence of detailed toxicity data. Although ketamine is currently the best-known member of the ACH family, the latter’s history began with the lead compound phencyclidine (PCP).
- 10.3390/ijms232415574
- 2022/12
- Int J Mol Sci. 2022 Dec; 23(24): 15574.
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Jan 13, 2024 · Arylcyclohexylamine Naming Conventions. There’s a general formula used to denote the name of a given arylcyclohexylamine — X-YCZ: X — refers to the substitutions made to the molecule and the site it’s attached to. Y — refers to the aromatic ring. In most cases, this is a P for “phenyl,” but there are other compounds that can be ...
Jan 1, 2016 · Original. Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1).
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Histamine is a chemical that's normally produced in your body and stored in allergic cells, such as mast cells and basophils. If you have allergies, histamine is released from these cells in a response to allergens. Your histamine binds to the histamine receptor , which is present on various cells in your body and results in allergic symptoms such ...
Antihistamines are commonly used for the treatment of various allergic diseases, and can be taken in oral, nasal spray, eye drop, and injected forms. The diseases antihistamines are used for include: Antihistamines are frequently used for the treatment of other allergic conditions, although they may not be as effective as they are for hay fever and...
Older antihistamines, such as Benadryl and Atarax, have a significant amount of anticholinergic side effects, including dry mouth, drowsiness, constipation, headache, and urinary retention. Because of the side effects of these medications, they are generally considered to be too sedating for routine daytime use. Since older antihistamines can impai...
- Daniel More, MD
Feb 12, 2024 · Molecular Structure of Ketamine Ketamine Chemical Classification. Ketamine is classified as an arylcyclohexylamine — which is a group of drugs characterized by the presence of a cyclohexane ring bound to an aromatic ring and containing an amine group.
Jan 1, 2022 · Methoxetamine (MXE) is an arylcyclohexylamine analogue of ketamine and has been available since 2010 as a novel psychoactive substance (NPS); it is often marketed as ‘bladder friendly’ in contrast to the urological side-effects associated with ketamine [279]. Case reports of human toxicity over the last decade demonstrate that in addition ...
