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- Sepsis is a person’s overwhelming or impaired whole-body immune response to an insult —an infection or an injury to the body, or something else that provokes such a response. Sepsis occurs unpredictably and can progress rapidly. In the worst cases, blood pressure drops, the heart weakens, and the patient spirals toward septic shock.
www.nigms.nih.gov › education › fact-sheets
Mar 21, 2019 · Sepsis is a medical emergency that describes the body’s systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death.
- Sepsis
With the help of systematic data and sample collection from...
- Clinical Aspects of Sepsis: An Overview
Sepsis is one of the oldest and most elusive syndromes in...
- Sepsis
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Where did sepsis come from?
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- Sepsis: The Beginning
- Sepsis in The 1800s
- Recent Developments
- Further Reading
Sepsis was first mentioned by scriptures in Ancient Greece. The word sepsis comes from the Greek word “sepo”, which means “I rot”, and has its first use in medical context in Homer’s poems. It is also mentioned in the writings of Hippocrates, a physician and philosopher, around 400 BC. He viewed sepsis as dangerous biological decay that could poten...
At the start of the golden age of germ theory, Ignaz Semmelweiss made monumental observations about puerperal sepsis, or sepsis that occurs after childbirth. He noticed that in his ward, women who had assistance from midwives during delivery developed puerperal sepsis 2% of the time, whereas those who had help from medical students developed it 16%...
The past 30 years have seen an increased focus on how to better understand and treat sepsis. In the early 1990s, a conference was held to come to some kind of consensus as to what sepsis was defined as. This was modified by the 2001 conference but ultimately lead to the development of a distinction between an infection, sepsis, severe sepsis, and s...
May 3, 2024 · Sepsis is usually caused by bacterial infections but may be the result of other infections such as viruses, parasites or fungi. Its treatment requires medical care, including the use of antimicrobials, intravenous fluids and other measures.
Feb 10, 2023 · Overview. Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock. This is a dramatic drop in blood pressure that can damage the lungs, kidneys, liver and other organs.
Jul 29, 2024 · With the help of systematic data and sample collection from patients with sepsis, NIGMS scientists are studying why some people develop the disease and respond to certain treatment while others don’t—insight that could lead to improved diagnosis, therapies, and outcomes.
Aug 5, 2005 · An important advance in sepsis pathophysiology has been the growing realization of the links between the coagulation system and the immune response to sepsis (7), which led to the development of the only specific antisepsis treatment currently available, recombinant human activated protein C (8).
Sep 24, 2014 · Sepsis is one of the oldest and most elusive syndromes in medicine. With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was considered as a systemic infection by a pathogenic organism.
