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      thelancet.com

      Approximately 1.3 million cases

      • There are approximately 1.3 million cases of neonatal sepsis reported worldwide with deaths occurring more commonly in preterm and low-weight newborns. Neonatal sepsis is the third major cause of neonatal deaths resulting in 203,000 deaths per year.
      www.ncbi.nlm.nih.gov › pmc › articles
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  2. Jan 22, 2021 · The Global Burden of Disease (GBD) estimated 1.3 million annual incident cases of neonatal sepsis and other infections (approximately 937 cases per 100 000 live births) and 203 000 sepsis-attributable neonatal deaths.

    • Figure 2

      Neonates are at major risk of sepsis, but data on neonatal...

  3. Sep 29, 2022 · Maternal administration of antibiotics and the low blood volume obtained for blood culture could explain the low rate of positive blood cultures. The incidence of sepsis is significantly higher in premature infants, as well as those with very low birth weight (<1000 grams).

    • Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
    • 2022/09/29
  4. We found in 26 studies a pooled neonatal sepsis incidence of 2824 sepsis cases per 100 000 live births (95% CI 1892 to 4194) and a mortality of 17.6% (95% CI 10.3% to 28.6%). Preterm and very low birthweight neonates were particularly affected, and there were considerable regional differences in incidence.

    • Carolin Fleischmann, Felix Reichert, Alessandro Cassini, Rosa Horner, Thomas Harder, Robby Markwart,...
    • 2021
    • What is the incidence of neonatal sepsis (NNS)?1
    • What is the incidence of neonatal sepsis (NNS)?2
    • What is the incidence of neonatal sepsis (NNS)?3
    • What is the incidence of neonatal sepsis (NNS)?4
  5. Sep 12, 2022 · Neonate sepsis makes a major public health burden of developing countries. 3 The prevalence of neonatal sepsis is about 1 to 10 per 1000 births in developed countries. 4 In a systemic review assessing the global burden of sepsis among neonates and children, it was reported that mortality due to sepsis can reach 20% of affected cases. 5 Neonatal ...

  6. Oct 1, 2020 · Although non-specific tests such as a complete blood count and inflammatory markers are often obtained in the initial assessment, the most important test is a blood culture with at least 1 mL of blood, drawn before administering antibiotics.

  7. Our estimates confirm that neonatal sepsis is an important contributor to neonatal morbidity worldwide, with a higher burden in LMICs. Based on the available evidence of 26 studies from 14 countries, we found an incidence of 2824 neonatal sepsis cases per 100 000 live births in the overall time frame.

  8. The incidence of sepsis is highest in neonates and children, yet the global burden of sepsis in these age groups has not been assessed. We reviewed available evidence from observational epidemiological studies to estimate the global burden and mortality of sepsis in neonates and children.

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