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How does a dengue virus affect platelets?
When do platelet counts drop in dengue?
How does thrombopoietin affect platelet count recovery in dengue fever?
Aug 12, 2022 · Hemorrhage and plasma leakage in dengue hemorrhagic fever result from vascular fragility due to impaired platelet functions. Several studies showed that the platelet count in dengue hemorrhagic fever (DHF)/dengue fever showed a significant decrease on the fourth day of the illness.
Feb 17, 2022 · On this regard, we highlight that the decrease in platelet counts may be due to bone marrow suppression or consumption of platelets at the periphery. We discuss the infection of hematopoietic progenitors and stromal cells as mechanisms involved in bone marrow suppression.
- Anna Cecíllia Quirino-Teixeira, Fernanda Brandi Andrade, Mariana Brandi Mendonça Pinheiro, Stephane ...
- 2021
Platelet transfusions do not decrease the risk of severe bleeding and may instead lead to fluid overload and prolonged hospitalization. X DON’T give half normal (0.45%) saline. Half normal saline should not be given, even as a maintenance fluid, because it leaks into third spaces and may lead to worsening of ascites and pleural efusions.
- 3MB
- 8
Nov 20, 2020 · The primary objective of this study is to investigate the value of a complete blood count (CBC) in determining the prognosis of dengue fever. The second objective is to observe the trends of recovery of white blood cells (WBCs) and platelets in dengue fever.
- Amogh Ananda Rao, Raaju R U, Siddharth Gosavi, Sanjana Menon
- 10.7759/cureus.11594
- 2020
- Cureus. 2020 Nov; 12(11): e11594.
Jan 31, 2017 · With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day 4 of fever in patients.
- Amrita Ojha, Dipika Nandi, Harish Batra, Rashi Singhal, Gowtham K. Annarapu, Sankar Bhattacharyya, T...
- 10.1038/srep41697
- 2017
- Sci Rep. 2017; 7: 41697.
Sep 28, 2023 · This phenomenon is a result of multiple complex mechanisms: 1. Direct Viral Action. The dengue virus has a direct impact on the bone marrow, where platelets are produced. Studies have shown that the virus can infect megakaryocytes, which are the precursor cells of platelets. This leads to a reduction in the production of platelets. 2.
Apr 12, 2023 · The platelet counts begin to drop during the febrile stage of dengue; defervescence heralds the onset of the toxic stage when the counts drop to a nadir. Bone marrow depression with impaired production of platelets is one of the key mechanisms of thrombocytopenia (Fig. 51.1 ).