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Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. [1] Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes.
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes.
Human lipoxygenases. With the exception of the gene encoding 5-LOX (ALOX5), which is located on chromosome 10q11.2, all six human LOX genes are located on chromosome 17.p13 and code for a single chain protein of 75–81 kilodaltons that consists of 662–711 amino acids.
Jan 13, 2015 · The 5-lipoxygenase protein (5LO) inserts molecular oxygen into free and esterified fatty acids with the aid of 5-lipoxygenase activating protein (FLAP). 5-lipoxygenase acts on arachidonic acid to produce 5-HPETE, which is metabolized into 5-HETE or leukotriene A4, depending on the cellular milieu.
LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane. Here, we contrast the structural and functional consequences of the binding of two natural product inhibitors of 5-LOX.
- Nathaniel C. Gilbert, Jana Gerstmeier, Erin E. Schexnaydre, Friedemann Börner, Ulrike Garscha, David...
- 10.1038/s41589-020-0544-7
- 2020
- 2020/07
5-Lipoxygenase (5-LOX) is a fundamental enzyme in the metabolism of arachidonic acid to leukotrienes. Several studies suggest that there is a link between 5-LOX and carcinogenesis in humans and animals.
Jun 6, 2004 · 5-lipoxygenase (5-LO) pathway is the major source of potent proinflammatory leukotrienes (LTs) issued from the metabolism of arachidonic acid (AA), and best known for their roles in the pathogenesis of asthma.
