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  1. Ceftriaxone - Wikipedia

    en.wikipedia.org/wiki/Ceftriaxone

    Ceftriaxone, sold under the brand name Rocephin, is an antibiotic used for the treatment of a number of bacterial infections. These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease.

    • C₁₈H₁₈N₈O₇S₃
    • AU: B1, US: B (No risk in non-human studies)
    • Negligible
    • Rocephin, Epicephin, Wintriaxone, others
  2. Cefotaxime - Wikipedia

    en.wikipedia.org/wiki/Cefotaxime

    However, ceftriaxone has the advantage of once-daily dosing, whereas the shorter half-life of cefotaxime necessitates two or three daily doses for efficacy. Changing patterns in microbial resistance suggest cefotaxime may be suffering greater resistance than ceftriaxone, whereas the two were previously considered comparable.

    • C₁₆H₁₇N₅O₇S₂
    • Claforan, others
    • AU: B1, US: B (No risk in non-human studies)
    • liver
  3. Ceftriaxone - WikEM

    www.wikem.org/wiki/Ceftriaxone
    • General
    • Adult Dosing
    • Pediatric Dosing
    • Special Populations
    • Contraindications
    • Adverse Reactions
    • Pharmacology
    • Antibiotic Sensitivities
    Type: 3rd generation Cephalosporin
    Dosage Forms: injectable solution, powder for injection
    Dosage Strengths: injectable solution: 1g/50mL, 2g/50mL; powder for injection: 250mg, 500mg, 1g, 2g, 10g, 100g
    Routes of Administration: IV, IM

    General

    1. 1-2g IM/IV q24h 2. First ED Dose: 1g IM/IV x 1 3. Max: 4g/24h

    Bacterial Meningitis

    1. 4g IV divided q12-24h x 7-21 days 2. First ED Dose: 2g IM/IV x 1

    1. Uncomplicated, initial: 250mg IM x 1 1.1. Also treat for chlamydia regardless of test results 2. Uncomplicated, recurrent of persistent: 500-1000mg IM x 1 3. Disseminated: 1g IM/IV q24h 3.1. May switch to cefixime PO after 24-48h if clinical improvement 4. Conjunctivitis: 1g IM x 1 5. Prophylaxis (sexual assault victims) 5.1. 250mg IM x 1

    General

    1. 50mg/kg IM/IV q24h 2. First Dose: 50mg/kg IM/IV x 1

    Acute Otitis Media

    1. 50mg/kg IM/IV x 1 2. Give 50mg/kg IM/IV q24h x 3 days for recurrent infection 3. Max 1g/dose

    Bacterial Meningitis

    1. 80-100mg/kg IV divided q12-24h x 7-21 days 2. First Dose: 100mg/kg IV x 1 3. Max: 4g/24h

    Lactation: Probably safe
    Renal Dosing
    Hepatic Dosing
    Allergy to class/drug (see also Cephalosporin Cross-reactivity)
    Patients <1 month old

    Serious

    1. Anaphylaxis 2. Broncospasm 3. Stevens-Johnson Syndrome 4. Toxic Epidermal Necrolysis 5. Erythema multiforme 6. Serum sickness 7. Pneumonitis 8. Neutropenia 9. Leukopenia 10. Hemolytic anemia 11. Thrombocytopenia 12. Hypoprothrombinemia 13. Agranulocytosis 14. Superinfection 15. Clostridium difficile 16. Colitis 17. Billiary/gallbladder sludge 18. Jaundice 19. Pancreatitis 20. Seizures 21. Nephrolithiasis 22. Lung/kidney calcium precipitate (neonates)

    Common

    1. Local infection site reaction 2. Eosinophilia 3. Thrombocytosis 4. Transaminitis 5. Diarrhea 6. Leukopenia

    Half-life: 5.8-8.7h, 15h (CrCl 5-15)
    Metabolism: CYP450
    Excretion: Primarily urine
    Mechanism of Action: bactericidal; inhibits cell wall synthesis

    Key

    1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia

  4. Ceftriaxone – Wikipedia tiếng Việt

    vi.wikipedia.org/wiki/Ceftriaxone

    Ceftriaxone có thể lắng đọng trong mật gây ra bùn mật, mật pseudolithiasis, và sỏi mật, đặc biệt ở trẻ em. Hạ prothrombin máu và xuất huyết cũng là các tác dụng phụ đáng chú ý.Suy thận sau thận ở trẻ em cũng được báo cáo.

    • AU: B1, US: B (Không rủi ro trong các nghiên cứu không trên người)
    • /ˌsɛftraɪˈæksoʊn/
    • Ceftriaxone Description
    • Ceftriaxone - Clinical Pharmacology
    • Indications and Usage For Ceftriaxone
    • Contraindications
    • Warnings
    • Precautions
    • Adverse Reactions
    • Overdosage
    • Dosage and Administration
    • Animal Pharmacology
    • How Supplied
    • Clinical Studies
    • References

    Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R, 7R)-7-[2-(2-Amino-4-thiazolyl) glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.The chemical formula of Ceftriaxone sodium is C 18H 16N 8Na 2O 7S 3•3.5H 2O. It has a c...

    Average plasma concentrations of Ceftriaxone following a single 30-minute intravenous (IV) infusion of a 0.5, 1 or 2 gram dose and intramuscular (IM) administration of a single 0.5 (250 mg/mL or 350 mg/mL concentrations) or 1 gram dose in healthy subjects are presented in Table 1.Table 1 Ceftriaxone Plasma Concentrations After Single Dose Administration*IV doses were infused at a constant rate over 30 minutes.ND = Not determined.Ceftriaxone was completely absorbed following IM administration...

    Before instituting treatment with Ceftriaxone for Injection appropriate specimens should be obtained for isolation of the causative organism and for determination of its susceptibility to the drug. Therapy may be instituted prior to obtaining results of susceptibility testing.To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ceftriaxone for Injection and other antibacterial drugs, Ceftriaxone for Injection should be used only to treat or prevent infections...

    HypersensitivityCeftriaxone for injection is contraindicated in patients with known hypersensitivity to Ceftriaxone, any of its excipients or to any other cephalosporin. Patients with previous hypersensitivity reactions to penicillin and other beta lactam antibacterial agents may be at greater risk of hypersensitivity to Ceftriaxone (see WARNINGS – Hypersensitivity ).NeonatesPremature neonates: Ceftriaxone for injection is contraindicated in premature neonates up to a postmenstrual age of 41...

    Hypersensitivity ReactionsBefore therapy with Ceftriaxone for injection is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins and other beta-lactam agents or other drugs. This product should be given cautiously to penicillin and other beta-lactam agent-sensitive patients. Antibacterial drugs should be administered with caution to any patient who has demonstrated some form of allergy, particular...

    Development of Drug-resistant BacteriaPrescribing Ceftriaxone in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Prolonged use of Ceftriaxone may result in overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken.Patients wi...

    Ceftriaxone is generally well tolerated. In clinical trials, the following adverse reactions, which were considered to be related to Ceftriaxone therapy or of uncertain etiology, were observed:LOCAL REACTIONS—pain, induration and tenderness was 1% overall. Phlebitis was reported in <1% after IV administration. The incidence of warmth, tightness or induration was 17% (3/17) after IM administration of 350 mg/mL and 5% (1/20) after IM administration of 250 mg/mL.GENERAL DISORDERS AND ADMINISTRAT...

    In the case of overdosage, drug concentration would not be reduced by hemodialysis or peritoneal dialysis. There is no specific antidote. Treatment of overdosage should be symptomatic.

    Ceftriaxone for injection may be administered intravenously or intramuscularly.Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution, to reconstitute Ceftriaxone for injection vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. Precipitation of Ceftriaxone for injection-calcium can also occur when Ceftriaxone for injection is mixed with calcium-containing solutions in the same IV administration line.Ceftriaxo...

    Concretions consisting of the precipitated calcium salt of Ceftriaxone have been found in the gallbladder bile of dogs and baboons treated with Ceftriaxone.These appeared as a gritty sediment in dogs that received 100 mg/kg/day for 4 weeks. A similar phenomenon has been observed in baboons but only after a protracted dosing period (6 months) at higher dose levels (335 mg/kg/day or more). The likelihood of this occurrence in humans is considered to be low, since Ceftriaxone has a greater plasm...

    Ceftriaxone for Injection, USP is supplied as a sterile crystalline powder in glass vials as follows:Ceftriaxone for Injection, USP is also supplied as a sterile crystalline powder in glass bottle in a Pharmacy Bulk Package, NOT FOR DIRECT INFUSION as follows:Storage ConditionsCeftriaxone for Injection, USP sterile powder should be stored at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Protect from light.Discard unused portion.Sterile, Nonpyrogenic, Preservative-free.The...

    Clinical Trials in Pediatric Patients With Acute Bacterial Otitis MediaIn two adequate and well-controlled U.S. clinical trials a single IM dose of Ceftriaxone was compared with a 10 day course of oral antibiotic in pediatric patients between the ages of 3 months and 6 years. The clinical cure rates and statistical outcome appear in the table below:Table 7 Clinical Efficacy in Pediatric Patients with Acute Bacterial Otitis MediaAn open-label bacteriologic study of Ceftriaxone without a compar...

    1. Barnett ED, Teele DW, Klein JO, et al. Comparison of Ceftriaxone and Trimethoprim-Sulfamethoxazole for Acute Otitis Media. Pediatrics. Vol. 99, No. 1, January 1997.Brands listed are the trademarks of their respective owners.Piramal Critical CareBethlehem, PA 18017, USAMade in India©2019 Piramal Critical CareRevised: April 2019

  5. Jul 04, 2020 · Easy-to-read patient leaflet for Ceftriaxone. Includes indications, proper use, special instructions, precautions, and possible side effects.

    • Third generation cephalosporins
    • What Do I Need to Tell My Doctor Before I Take Ceftriaxone?
      For all patients taking ceftriaxone: 1. If you have an allergy to ceftriaxone or any other part of ceftriaxone. 2. If you are allergic to any drugs...
    • What Are Some Things I Need to Know Or Do While I Take Ceftriaxone?
      1. Tell all of your health care providers that you take ceftriaxone. This includes your doctors, nurses, pharmacists, and dentists. 2. Very bad and...
    • How Is This Medicine (Ceftriaxone) Best Taken?
      Use ceftriaxone as ordered by your doctor. Read all information given to you. Follow all instructions closely. 1. It is given as a shot into a musc...
    • What Are Some Side Effects That I Need to Call My Doctor About Right away?
      WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor o...
    • What Are Some Other Side Effects of Ceftriaxone?
      All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help i...
    • How Do I Store and/or Throw Out Ceftriaxone?
      1. If you need to store ceftriaxone at home, talk with your doctor, nurse, or pharmacist about how to store it.
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  7. Ceftriaxonă - Wikipedia

    ro.wikipedia.org/wiki/Ceftriaxonă

    Date chimice; Formulă: C₁₈H₁₈N₈O₇S₃ : Masă molară: 554,046058 u.a.m. Ceftriaxona este un antibiotic din clasa cefalosporinelor de generația a treia, utilizat în tratamentul unor infecții bacteriene.

  8. Ceftriaxone (injection) Uses, Side Effects & Warnings - Drugs.com

    www.drugs.com/mtm/ceftriaxone-injection.html

    Dec 02, 2019 · Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic.It works by fighting bacteria in your body. Ceftriaxone is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis.

    • Before Taking This Medicine
      Do not use ceftriaxone in a child without a doctor's advice, and never give more than the child's prescribed dose. Ceftriaxone injection can be dan...
    • How Should I Use Ceftriaxone?
      Ceftriaxone is injected into a muscle, or into a vein through an IV.A healthcare provider will give you this injection when ceftriaxone is used to...
    • What Should I Avoid While Using Ceftriaxone?
      Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...
    • What Other Drugs Will Affect Ceftriaxone?
      Other drugs may interact with ceftriaxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor a...
  9. Ceftriaxone Injection: Uses, Side Effects, Interactions ...

    www.webmd.com/drugs/2/drug-7013/ceftriaxone...
    • Administration
    • Prevention
    • Preparation
    • Treatment
    • Prognosis

    This medication is given by injection into a muscle or vein as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. Drink plenty of fluids while using this medication unless your doctor directs you otherwise.

    If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Avoid mixing ceftriaxone with IV fluids that have calcium in them (such as Ringer's solution, Hartmann's solution, parenteral nutrition-TPN/PPN). Consult your pharmacist for details about the safe use of IV calcium products in infants, children, and adults (see Precautions section). Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

    If you are using the frozen pre-mixed solution, thaw the bag at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature at least 1 hour before using. Do not thaw by putting in a water bath or microwaving. After thawing, shake well and squeeze the bag to check for leaks. Discard solution if the bag leaks. Do not re-freeze the solution after thawing.

    For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.

    Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

  10. Ceftriaxona – Wikipédia, a enciclopédia livre

    pt.wikipedia.org/wiki/Ceftriaxona

    Propriedades Fórmula química: C 18 H 18 N 8 O 7 S 3: Massa molar: 554.54 g mol-1: Ponto de fusão > 155 °C (decompõe-se) (Ceftriaxon-Hemi-hepta-hidrato de dissódio) [2] Farmacologia