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  1. Cefuroxime - Wikipedia

    en.wikipedia.org/wiki/Cefuroxime

    Cefuroxime, sold under the brand name Zinacef among others, is an antibiotic used to treat and prevent a number of bacterial infections. These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme disease.

    • Medical uses

      As with the other cephalosporins, it is susceptible to...

    • Side effects

      Cefuroxime is generally well tolerated, and its side effects...

    • Chemistry

      Cefuroxime axetil is an acetoxyethyl ester prodrug of...

    • Trade names

      In the U.S. it is marketed as Zinacef by Covis...

  2. Cefuroxime axetil - Wikipedia

    en.wikipedia.org/wiki/Cefuroxime_axetil

    Cefuroxime axetil, sold under the brand name Ceftin among others, is a second generation oral cephalosporin antibiotic. It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally. The activity depends on in vivo hydrolysis and release of cefuroxime tablets. It was patented in 1976 and approved for medical use in 1987.

    • C₂₀H₂₂N₄O₁₀S
    • Zinnat, Ceftin, Ceftum
    • Oral, IV, IM
    • Cefuroxime is not metabolized, Axetil is metabolized to acetaldehyde and acetic acid.
  3. Cefuroxime - WikEM

    www.wikem.org/wiki/Cefuroxime
    • General
    • Adult Dosing
    • Pediatric Dosing
    • Special Populations
    • Contraindications
    • Adverse Reactions
    • Pharmacology
    • Antibiotic Sensitivities
    Type: 2nd generation cephalosporin
    Dosage Forms: tablet, powder for injection
    Dosage Strength: tablet: 250mg, 500mg; powder for injection: 750mg, 1.5g, 7.5g, 75g, 225g
    Routes of Administration: PO, IV, IM

    Mild-Moderate Bacterial infections

    1. 250-500mg PO BID x5-10 days

    Steptococcal Pharyngitis/Tonsillitis

    1. 250mg PO BID x10 days

    Acute Maxillary Sinusitis

    1. 250mg PO BID x10 days; Info: not recommended per IDSA guidelines

    Mild-Moderate Bacterial Infections

    1. 3 mo-12 yo: Dose: 30mg/kg/day susp PO divided q12h x10 days; Max: 1000mg/day; Alt: 250mg tab PO BID x10 days; Info: give susp with food 2. >13 yo: Dose: 250-500mg tab PO BID x5-10 days; Info: dose, duration varies by infection type, severity

    1. 2 mo-5 yo Dose: 30mg/kg/day susp PO divided q12h x10 days; Max: 1000mg/day; Alt: 250mg tab PO BID x10 days; Info: give susp with food 2. 6-12 yo: Dose: 30mg/kg/day susp PO divided q12h x5-10 days; Max: 1000mg/day; Alt: 250mg tab PO BID x5-10 days; Info: give susp with food

    Acute Maxillary Sinusitis

    1. 3 mo-12 yo: Dose: 30mg/kg/day susp PO divided q12h x10 days; Max: 1000mg/day; Alt: 250mg tab PO BID x10 days; Info: not recommended per IDSA guidelines; give susp with food 2. >13 yo: Dose: 250mg tab PO BID x10 days; Info: not recommended per IDSA guidelines

    Pregnancy: B
    Lactation: Probably Safe
    Renal Dosing
    Hepatic Dosing
    Allergy to class/drug (See Cephalosporin Cross-reactivity)
    Caution if hypersensitive to PCN
    Caution if renal impairment
    Caution if hepatic impairment

    Serious

    1. Anaphylaxis 2. Angioedema 3. Toxic epidermal necrolysis 4. Stevens-Johnson syndrome 5. Interstitial nephritis 6. Pancytopenia 7. Thrombocytopenia 8. Agranulocytosis 9. Leukopenia 10. Neutropenia 11. Hemolytic Anemia 12. Seizures 13. Clostridium difficileassociated diarrhea

    Common

    1. Diarrhea 2. Nausea/Vomiting 3. Jarisch-Herxheimer reaction 4. Vaginitis 5. Diaper Rash 6. ALT, AST elevated 7. Renal Impairment 8. Anemia

    Half-life: 1.4 hours, 3.5 hours (CrCl 35),
    Metabolism: Minimal; CYP 450: unknown
    Excretion: Urinary primarily (Up to 100% unchanged)
    Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

    Key

    1. Ssusceptible/sensitive (usually) 2. Iintermediate (variably susceptible/resistant) 3. Rresistant (or not effective clinically) 4. S+synergistic with cell wall antibiotics 5. Usensitive for UTI only (non systemic infection) 6. X1no data 7. X2active in vitro, but not used clinically 8. X3active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis 9. X4active in vitro, but not clinically effective for strep pneumonia

  4. Cefuroxime Uses, Side Effects & Warnings - Drugs.com

    www.drugs.com/mtm/cefuroxime.html

    May 18, 2020 · Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cefuroxime is used to treat many kinds of bacterial infections, including severe or life-threatening forms. Cefuroxime may also be used for purposes not listed in this medication guide.

    • Zinacef, Ceftin
    • Second generation cephalosporins
    • Before Taking This Medicine
      Do not take this medicine if you are allergic to cefuroxime, or to other cephalosporin antibiotics, such as: 1. cefaclor (Raniclor); 2. cefadroxil...
    • How Should I Take Cefuroxime?
      Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.You may tak...
    • What Happens If I Miss A Dose?
      Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
    • What Happens If I Overdose?
      Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include seizure (black-out or convulsions).
    • What Should I Avoid While Taking Cefuroxime?
      Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...
    • What Other Drugs Will Affect Cefuroxime?
      Tell your doctor about all your current medicines and any you start or stop using, especially: 1. probenecid (Benemid); 2. a blood thinner such as...
  5. Cefuroxime: MedlinePlus Drug Information

    medlineplus.gov/druginfo/meds/a601206.html
    • Medical uses
    • Administration
    • Safety
    • Treatment
    • Risks
    • Diet
    • Prevention
    • Diagnosis
    • Preparation

    Cefuroxime is used to treat certain infections caused by bacteria, such as bronchitis(infection of the airway tubes leading to the lungs); gonorrhea (a sexually transmitted disease); Lyme disease (an infection that may develop after a person is bitten by a tick); and infections of the skin, ears, sinuses, throat, tonsils,, and urinary tract. Cefuroxime is in a class of medications called cephalosporin antibiotics. It works by stopping the growth of bacteria.

    Cefuroxime comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken every 12 hours for 5-10 days, depending on the condition being treated. To treat gonorrhea, cefuroxime is taken as a single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for 20 days. Take the suspension with food; the tablet may be taken with or without food . Take cefuroxime at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cefuroxime exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

    The tablets should be swallowed whole. Because the crushed tablet has a strong bitter taste, the tablet should not be crushed. Children who cannot swallow the tablet whole should take the liquid instead.

    You should begin to feel better during the first few days of treatment with cefuroxime. If your symptoms do not improve or get worse, call your doctor. Take cefuroxime until you finish the prescription, even if you feel better. If you stop taking cefuroxime too soon or skip doses, your infection may not be completely treated, and the bacteria may become resistant to antibiotics.

    Cefuroxime is also sometimes used to treat pneumonia. Talk to your doctor about the risks of using this medication for your condition. Cefuroxime may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

    Unless your doctor tells you otherwise, continue your normal diet. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Keep liquid medicine in the refrigerator, tightly closed, and dispose of any unused medication after 10 days. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. http://www.upandaway.org

    Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to cefuroxime. If you are diabetic and test your urine for sugar, use Clinistix or TesTape (not Clinitest) to test your urine while taking this medication. If you test your blood for sugar, check with your doctor or pharmacist to recommend the best product to use while taking this medication.

    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  6. Cefuroxime sodium | C16H15N4NaO8S - PubChem

    pubchem.ncbi.nlm.nih.gov/compound/Cefuroxime-sodium

    Cefuroxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.

  7. People also ask

    What is cefuroxime axetil used for?

    Is cefuroxime used for UTI?

    What conditions does cefixime treat?

    • Indications & Usage
    • Cefuroxime Axetil Dosage and Administration
    • Dosage Forms & Strengths
    • Contraindications
    • Warnings and Precautions
    • Adverse Reactions
    • Drug Interactions
    • Use in Specific Populations
    • Overdosage
    • Cefuroxime Axetil Description
    • Nonclinical Toxicology
    • Clinical Studies
    • How Supplied/Storage and Handling
    • Patient Counseling Information
    • Package/Label Display Panel – Carton – 250 Mg

    Cefuroxime Axetil tablets are indicated for the treatment of adult patients and pediatric patients (13 years and older) with mild-to-moderate pharyngitis/tonsillitis caused by susceptible strains of Streptococcus pyogenes.Limitations of Use 1. The efficacy of Cefuroxime Axetil in the prevention of rheumatic fever was not established in clinical trials. 2. The efficacy of Cefuroxime Axetil in the treatment of penicillin-resistant strains of Streptococcus pyogenes has not been demonstrated in c...

    1. Cefuroxime Axetil tablets and Cefuroxime Axetil for oral suspension are not bioequivalent and are therefore not substitutable on a milligram-per-milligram basis [see Clinical Pharmacology ( 12.3)]. 2. Administer Cefuroxime Axetil tablets as described in the appropriate dosage guidelines [see Dosage and Administration ( 2.2)]. 3. Administer Cefuroxime Axetil tablets with or without food. 4. Pediatric patients (aged 13 years and older) who cannot swallow the Cefuroxime Axetil tablets whole...

    Cefuroxime Axetil tablets, USP 250 mg of cefuroxime (as Cefuroxime Axetil), are blue, capsule-shaped, biconvex, film-coated tablets with “204” debossed on one side and plain on the other sideCefuroxime Axetil Tablets, USP 500 mg of cefuroxime (as Cefuroxime Axetil), are blue, capsule-shaped, biconvex, film-coated tablets with 203” debossed on one side and plain on the other side.

    Cefuroxime Axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to Cefuroxime Axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins).

    Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on β-lactam antibacterials. These reactions are more likely to occur in individuals with a history of β-lactam hypersensitivity and/or a history of sensitivity to multiple allergens. There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe reactions when treated with cephalosporins. Cefuroxime Axetil is contraindicated in patients with...

    The following serious and otherwise important adverse reaction is described in greater detail in the Warnings and Precautions section of the label:Anaphylactic Reactions [see Warnings and Precautions ( 5.1)]

    Cefuroxime Axetil may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives. Counsel patients to consider alternate supplementary (non-hormonal) contraceptive measures during treatment.

    Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Cefuroxime Axetil should be used during pregnancy only if clearly needed.Reproduction studies have been performed in mice at doses up to 3,200 mg/kg/day (14 times the recommended maximum human dose based on body surface area) and in rats at doses up to 1,000 mg/kg/day (9 times the recommended maximum human dose based on bod...

    Overdosage of cephalosporins can cause cerebral irritation leading to convulsions or encephalopathy. Serum levels of cefuroxime can be reduced by hemodialysis and peritoneal dialysis.

    Cefuroxime Axetil tablets, USP contain cefuroxime as Cefuroxime Axetil. Cefuroxime Axetil is a semisynthetic, cephalosporin antibacterial drug for oral administration.The chemical name of Cefuroxime Axetil (1-(acetyloxy) ethyl ester of cefuroxime) is ( RS)-1 hydroxyethyl (6 R,7 R)-7-[2-(2-furyl)glyoxyl-amido]-3-(hydroxymethyl)-8-oxo-5-thia-1 azabicyclo[4.2.0]-oct-2-ene-2-carboxylate, 72-( Z)-( O-methyl-oxime), 1-acetate 3-carbamate. Its molecular formula is C 20H 22N 4O 10S, and it has a mole...

    Although lifetime studies in animals have not been performed to evaluate carcinogenic potential, no mutagenic activity was found for Cefuroxime Axetil in a battery of bacterial mutation tests. Positive results were obtained in an in vitro chromosome aberration assay; however, negative results were found in an in vivo micronucleus test at doses up to 1.5 g/kg. Reproduction studies in rats at doses up to 1,000 mg/kg/day (9 times the recommended maximum human dose based on body surface area) hav...

    One adequate and well-controlled trial was performed in subjects with acute bacterial maxillary sinusitis. In this trial, each subject had a maxillary sinus aspirate collected by sinus puncture before treatment was initiated for presumptive acute bacterial sinusitis. All subjects had radiographic and clinical evidence of acute maxillary sinusitis. In the trial, the clinical effectiveness of Cefuroxime Axetil in treating acute maxillary sinusitis was comparable to an oral antimicrobial agent c...

    Cefuroxime Axetil tablets, USP 250 mg of cefuroxime (as Cefuroxime Axetil), are blue, capsule-shaped, biconvex, film-coated tablets with “204” debossed on one side and plain on the other side as follows:Unit dose packages of 20 (2 x 10) NDC 60687-272-94Store at 20° to 25°C (68° to 77°F). [See USP controlled room temperature].FOR YOUR PROTECTION: Do not use if blister is torn or broken.

    Allergic ReactionsInform patients that Cefuroxime Axetil is a cephalosporin that can cause allergic reactions in some individuals [see Warnings and Precautions ( 5.1)].Clostridium difficile-associated DiarrheaInform patients that diarrhea is a common problem caused by antibacterials, and it usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibacterials, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as...

    NDC 60687-272-94Cefuroxime AxetilTABLETS, USP250 mg*20 Tablets (2 x 10)*Each Tablet Contains:Cefuroxime Axetil USP equivalent to 250 mgof cefuroxime.Usual Dosage: See package insert for fullprescribing information.Store at 20° to 25°C (68° to 77°F).[see USP Controlled Room Temperature].Keep this and all drugs out of reach of children.FOR YOUR PROTECTION: Do not use if blisteris torn or broken.Rx OnlyManufactured by:ALKEM LABORATORIES LTD.Mumbai - 400013, IndiaDistributed by:American Health Pa...

  8. Cefuroximă - Wikipedia

    ro.wikipedia.org/wiki/Cefuroximă

    Ultima editare a paginii a fost efectuată la 17 iunie 2019, ora 23:32. Acest text este disponibil sub licența Creative Commons cu atribuire și distribuire în condiții identice; pot exista și clauze suplimentare.

  9. Cefotaxime - Wikipedia

    en.wikipedia.org/wiki/Cefotaxime

    Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis.

  10. Cefuroxime Dosage Guide with Precautions - Drugs.com

    www.drugs.com/dosage/cefuroxime.html

    May 18, 2020 · Detailed Cefuroxime dosage information for adults and children. Includes dosages for Bacterial Infection, Urinary Tract Infection, Sinusitis and more; plus renal, liver and dialysis adjustments.

    • Usual Adult Dose For Bacterial Infection
      Oral (tablets): 250 or 500 mg orally every 12 hoursParenteral: 750 mg to 1.5 g IV or IM every 8 hours-Life-threatening infections or infections due...
    • Usual Adult Dose For Bronchitis
      Oral (tablets): 250 or 500 mg orally every 12 hours for 10 daysParenteral: 750 mg to 1.5 g IV or IM every 8 hoursComments:-Oral: Safety and efficac...
    • Usual Adult Dose For Pneumonia
      Uncomplicated infections: 750 mg IV or IM every 8 hoursSevere or complicated infections: 1.5 g IV or IM every 8 hoursUse: For the treatment of lowe...
    • Usual Adult Dose For Urinary Tract Infection
      Uncomplicated infections:-Oral (tablets): 250 mg orally every 12 hours for 7 to 10 days-Parenteral: 750 mg IV or IM every 8 hoursSevere or complica...
    • Usual Adult Dose For Skin Or Soft Tissue Infection
      Oral (tablets): 250 to 500 mg orally every 12 hours for 10 daysParenteral: 750 mg IV or IM every 8 hours-Severe or complicated infections: 1.5 g IV...
    • Usual Adult Dose For Septicemia
      Life-threatening infections or infections due to less susceptible organisms: 1.5 g IV every 6 hoursUse: For the treatment of septicemia due to S au...
    • Usual Adult Dose For Meningitis
      Life-threatening infections or infections due to less susceptible organisms: 1.5 g IV every 6 hours-Maximum dose: 3 g IV every 8 hoursUse: For the...
    • Usual Adult Dose For Joint Infection
      1.5 g IV or IM every 8 hoursComments:-In clinical trials, adjunctive therapy included surgical intervention when indicated; when appropriate, oral...
    • Usual Adult Dose For Surgical Prophylaxis
      Clean-contaminated or potentially contaminated surgical procedures:-Preoperative: 1.5 g IV 30 to 60 minutes before the initial incision-Intraoperat...
    • Usual Adult Dose For Tonsillitis/Pharyngitis
      Tablets: 250 mg orally every 12 hours for 10 daysComments:-Efficacy in the prevention of rheumatic fever not established in clinical trials.-Effica...