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    • Are there different definitions of neonatal sepsis?

      • There are multiple definitions of neonatal sepsis used internationally that encompass clinical, microbiological and biochemical data as well as treatment initiation and duration. The difficulties in comparing early and late onset sepsis as well as differences between term and preterm infants make a single definition or management plan challenging.
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    Are there different definitions of neonatal sepsis?

    Is the sepsis definition accurate for a preterm baby?

    Why is there no consensus definition of sepsis?

    Is the rate of sepsis decreasing in NICU?

  2. The pediatric consensus definition for sepsis, established in 2005 to support the trial of activated protein C for the treatment of pediatric sepsis, was intended for all children (<18 years old) and including term (≥37 weeks completed gestation) neonates . Preterm neonates (<37 weeks completed gestation) were specifically excluded from the pediatric consensus definitions and neonatal-perinatal subspecialists were not represented among the international pediatric consensus experts.

    • James L. Wynn
    • 234
    • 2016
  3. Recent findings: Pediatric consensus definitions for sepsis are not accurate in term infants and are not appropriate for preterm infants. In contrast to the defined multistage criteria for other devastating diseases encountered in the NICU (e.g., bronchopulmonary dysplasia), there is significant variability in the criteria used by investigators to substantiate the diagnosis of neonatal sepsis.

    • James L. Wynn
    • 234
    • 2016
  4. Mar 19, 2020 · In addition to the lack of an internationally accepted consensus definition of neonatal sepsis, there are no definitions associated with long-term outcomes.

    • Eleanor J. Molloy, James L. Wynn, Joseph Bliss, Joyce M. Koenig, Fleur M. Keij, Matt McGovern, Helmu...
    • 14
    • 2020
  5. Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response. Thus, specific consensus definitions for both term and preterm neonates are needed.

    • James L. Wynn, Hector R. Wong, Hector R. Wong, Thomas P. Shanley, Matthew J. Bizzarro, Lisa Saiman, ...
    • 272
    • 2014
  6. Jun 19, 2019 · Neonatal sepsis is a diagnosis made in infants less than 28 days of life and consists of a clinical syndrome that may include systemic signs of infection, circulatory shock, and multisystem organ failure. Neonatal sepsis may be divided into two types: early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS).

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