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Bonnie Bassler Biography, Explorer's Guide to Biology. Bonnie Lynn Bassler (born 1962) [2] is an American molecular biologist; the Squibb Professor in Molecular Biology and chair of the Department of Molecular Biology at Princeton University; and a Howard Hughes Medical Institute Investigator.
- Bonnie Lynn Bassler, 1962 (age 60–61), Chicago, Illinois, U.S.
- Todd Reichart
- United States
- Quorum sensing
I joined Silverman’s lab in 1990 to study Vibrio harveyi, a free-living bioluminescent bacterium. We showed that V harveyi had two autoinducers, two cognate receptors, and a protein linking the two systems. To our surprise, we found that the V harveyi quorum-sensing components did not resemble LuxI and LuxR of V fischeri.
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Oct 24, 2013 · Bonnie Bassler of Princeton University and the Howard Hughes Medical Institute has revolutionized the way that we think about microbiology. She elucidated the chemical language that bacteria use to communicate through a process called quorum sensing that allows bacteria to count their numbers, determine when they’ve reached a critical mass ...
- Ushma S. Neill
- 10.1172/JCI75027
- 2014
- J Clin Invest. 2014 Apr 1; 124(4): 1421-1422.
She is a Howard Hughes Medical Institute Investigator and the Squibb Professor and Chair of the Department of Molecular Biology at Princeton University. Bassler received a B.S. in Biochemistry from the University of California at Davis, and a Ph.D. in Biochemistry from the Johns Hopkins University.
The research in her laboratory focuses on the molecular mechanisms that bacteria use for intercellular communication. This process is called quorum sensing. Bassler’s research is paving the way to the development of novel therapies for combating bacteria by disrupting quorum-sensing-mediated communication.
Jan 5, 2022 · Bassler, Princeton's Squibb Professor in Molecular Biology and the chair of the department, has spent her career investigating how bacteria talk to each other and orchestrate collective behaviors. This process, called quorum sensing, relies on the production, detection and response to extracellular signal molecules.
Bonnie Bassler discovered that bacteria "talk" to each other, using a chemical language that lets them coordinate defense and mount attacks. The find has stunning implications for medicine, industry -- and our understanding of ourselves.