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  1. De Soto is a city in Jefferson County, Missouri, United States. The population was 6,449 at the 2020 census and the city is part of the St. Louis metropolitan area. The Van Metre family were first to settle in 1803.

  2. Dec 28, 2020 · Things to Do in De Soto, Missouri: See Tripadvisor's 495 traveler reviews and photos of De Soto tourist attractions. Find what to do today, this weekend, or in September. We have reviews of the best places to see in De Soto. Visit top-rated & must-see attractions.

  3. 2 days ago · The City of De Soto is located in the southeastern part of Missouri, approximately 45 miles south of St. Louis. De Soto is in Jefferson County, which is one of the fastest growing counties in Missouri.

  4. De Soto is a city in Jefferson County, Missouri, United States. The population was 6,449 at the 2020 census and the city is part of the St. Louis metropolitan area. Overview

  5. De Soto Tourism: Tripadvisor has 495 reviews of De Soto Hotels, Attractions, and Restaurants making it your best De Soto resource.

  6. The City of De Soto is located in the southeastern part of Missouri, approximately 45 miles south of St. Louis. De Soto is in Jefferson County, which is one of the fastest growing counties in Missouri.

  7. In 2022, De Soto, MO had a population of 6.43k people with a median age of 34 and a median household income of $44,788. Between 2021 and 2022 the population of De Soto, MO grew from 6,429 to 6,430, a 0.0156% increase and its median household income grew from $41,515 to $44,788, a 7.88% increase.

  8. Welcome to the De Soto, Missouri Chamber of Commerce. Our beautiful city was incorporated in 1869. It was named in honor of the Spanish explorer Hernando De Soto who claimed the Louisiana Territory for Spain.

  9. This city, located along the Mississippi River, played a crucial role in the westward expansion of the United States. Its iconic Gateway Arch stands as a symbol of this historical significance, inviting people to learn about the city's past and its role as a gateway to the western frontier.

  10. Vineland Elementary. District of Desoto 73. Lowest grade : K, Highest grade : 6. Students : 819. Middle schools in De Soto.

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